Semaphorin4B is elevated in rheumatoid arthritis and enhances the inflammatory phenotype of macrophages and fibroblast-like synoviocytes

Semaphorin4B is elevated in rheumatoid arthritis and enhances the inflammatory phenotype of macrophages and fibroblast-like synoviocytes

Abstract Background Several members of the class 4 semaphorins are involved in the pathogenesis of rheumatoid arthritis (RA), regulating proinflammatory functions, but the role of (Sema)phorin4B remains unexplored. Therefore, the aim of this study was to determine the expression and function of Sema...

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Main Authors: Sara Martínez-Ramos, Carlos Rafael-Vidal, Jaime Marty, Beatriz Malvar-Fernández, Coral Mouriño, Nair Pérez, Irene Altabás, Francisco J. Maceiras Pan, David Fernández-Fernández, Carmen Conde, Megan M. Hanlon, Conor M. Smith, Paul Peter Tak, Douglas J. Veale, Ursula Fearon, Jose María Pego-Reigosa, Samuel García
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Semaphorin4B
Rheumatoid arthritis
Synovium
Fibroblast-like synoviocytes
Macrophages
Inflammation
Online Access:https://doi.org/10.1186/s13075-025-03592-x
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