Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease?
Background: Eosinophilic esophagitis (EoE) has been described as a chronic allergen/immune-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic infiltration of the mucosa. Summary: Over the past decades, EoE has been increasingly recognized in various geog...
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Karger Publishers
2025-01-01
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| Series: | Inflammatory Intestinal Diseases |
| Online Access: | https://karger.com/article/doi/10.1159/000543022 |
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| author | Robin Mona Petr Hruz |
| author_facet | Robin Mona Petr Hruz |
| author_sort | Robin Mona |
| collection | DOAJ |
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Background: Eosinophilic esophagitis (EoE) has been described as a chronic allergen/immune-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic infiltration of the mucosa. Summary: Over the past decades, EoE has been increasingly recognized in various geographical areas with a high socioeconomic development (mostly industrialized countries) and has evolved from an unknown to a clinically distinct disease with increasing prevalence and incidence. An average age at diagnosis between 30 and 50 years and a male predominance have been consistently observed. In both children and adults, EoE is clearly associated with allergies, predominantly food – but also aeroallergens. Most EoE patients present with a personal allergic background such as asthma, rhino-conjunctivitis, and oral allergy syndrome. Key Message: Knowledge of epidemiological characteristics is crucial for identifying risk factors and understanding of the pathogenic mechanisms. Background: Eosinophilic esophagitis (EoE) has been described as a chronic allergen/immune-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic infiltration of the mucosa. Summary: Over the past decades, EoE has been increasingly recognized in various geographical areas with a high socioeconomic development (mostly industrialized countries) and has evolved from an unknown to a clinically distinct disease with increasing prevalence and incidence. An average age at diagnosis between 30 and 50 years and a male predominance have been consistently observed. In both children and adults, EoE is clearly associated with allergies, predominantly food – but also aeroallergens. Most EoE patients present with a personal allergic background such as asthma, rhino-conjunctivitis, and oral allergy syndrome. Key Message: Knowledge of epidemiological characteristics is crucial for identifying risk factors and understanding of the pathogenic mechanisms. |
| format | Article |
| id | doaj-art-b755d52ae9324626a867ebd6db5b0d03 |
| institution | OA Journals |
| issn | 2296-9365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Karger Publishers |
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| series | Inflammatory Intestinal Diseases |
| spelling | doaj-art-b755d52ae9324626a867ebd6db5b0d032025-08-20T02:31:55ZengKarger PublishersInflammatory Intestinal Diseases2296-93652025-01-01101344010.1159/000543022Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease?Robin MonaPetr Hruzhttps://orcid.org/0000-0003-2767-0445 Background: Eosinophilic esophagitis (EoE) has been described as a chronic allergen/immune-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic infiltration of the mucosa. Summary: Over the past decades, EoE has been increasingly recognized in various geographical areas with a high socioeconomic development (mostly industrialized countries) and has evolved from an unknown to a clinically distinct disease with increasing prevalence and incidence. An average age at diagnosis between 30 and 50 years and a male predominance have been consistently observed. In both children and adults, EoE is clearly associated with allergies, predominantly food – but also aeroallergens. Most EoE patients present with a personal allergic background such as asthma, rhino-conjunctivitis, and oral allergy syndrome. Key Message: Knowledge of epidemiological characteristics is crucial for identifying risk factors and understanding of the pathogenic mechanisms. Background: Eosinophilic esophagitis (EoE) has been described as a chronic allergen/immune-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic infiltration of the mucosa. Summary: Over the past decades, EoE has been increasingly recognized in various geographical areas with a high socioeconomic development (mostly industrialized countries) and has evolved from an unknown to a clinically distinct disease with increasing prevalence and incidence. An average age at diagnosis between 30 and 50 years and a male predominance have been consistently observed. In both children and adults, EoE is clearly associated with allergies, predominantly food – but also aeroallergens. Most EoE patients present with a personal allergic background such as asthma, rhino-conjunctivitis, and oral allergy syndrome. Key Message: Knowledge of epidemiological characteristics is crucial for identifying risk factors and understanding of the pathogenic mechanisms. https://karger.com/article/doi/10.1159/000543022 |
| spellingShingle | Robin Mona Petr Hruz Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease? Inflammatory Intestinal Diseases |
| title | Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease? |
| title_full | Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease? |
| title_fullStr | Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease? |
| title_full_unstemmed | Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease? |
| title_short | Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease? |
| title_sort | epidemiology of eosinophilic esophagitis really a novel and evolving disease |
| url | https://karger.com/article/doi/10.1159/000543022 |
| work_keys_str_mv | AT robinmona epidemiologyofeosinophilicesophagitisreallyanovelandevolvingdisease AT petrhruz epidemiologyofeosinophilicesophagitisreallyanovelandevolvingdisease |