Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.

Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.

We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii) novel inhibitors, which target single or multiple...

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Bibliographic Details
Main Authors: Jatinder K Juss, Richard P Hayhoe, Charles E Owen, Ian Bruce, Sarah R Walmsley, Andrew S Cowburn, Suhasini Kulkarni, Keith B Boyle, Len Stephens, Phillip T Hawkins, Edwin R Chilvers, Alison M Condliffe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045933&type=printable
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