Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study

Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study

IntroductionCorticosteroids are used for toxicity management, raising concerns about whether they may affect the anti-leukemic effects of chimeric antigen receptor (CAR)-T cells.Methods and resultsIn this study, we retrospectively analyzed patients (fined two subgroups based on disease burden. Of th...

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Main Authors: Jing Yang, Jing Zhang, Xinyu Wan, Jiaoyang Cai, Tianyi Wang, Xiaomin Yang, Wenjie Li, Lixia Ding, Lili Song, Yan Miao, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang, Benshang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pediatrics
Subjects:
leukemia
Chimeric antigen receptor
cytokine release syndrome
corticosteroids
children
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2024.1485402/full
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