Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD
IntroductionObsessive-compulsive disorder (OCD) is a challenging neuropsychiatric condition with a subset of patients remaining refractory to conventional treatments. Deep brain stimulation (DBS) of the bed nucleus of the stria terminalis (BNST) has shown promise for severe, treatment-resistant OCD....
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Frontiers Media S.A.
2025-01-01
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| author | Jean-Baptiste Belge Jean-Baptiste Belge Vincent Geenen Anne L. Salado Bruno Kaschten Didier Martin Gabrielle Scantamburlo Gabrielle Scantamburlo |
| author_facet | Jean-Baptiste Belge Jean-Baptiste Belge Vincent Geenen Anne L. Salado Bruno Kaschten Didier Martin Gabrielle Scantamburlo Gabrielle Scantamburlo |
| author_sort | Jean-Baptiste Belge |
| collection | DOAJ |
| description | IntroductionObsessive-compulsive disorder (OCD) is a challenging neuropsychiatric condition with a subset of patients remaining refractory to conventional treatments. Deep brain stimulation (DBS) of the bed nucleus of the stria terminalis (BNST) has shown promise for severe, treatment-resistant OCD. This case report examines the relationship between plasma oxytocin levels and OCD symptom severity following BNST-DBS.MethodsA 36-year-old patient with long-standing, treatment-resistant OCD underwent stereotactic implantation of DBS electrodes at the BNST. Postoperative assessments included OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and plasma oxytocin levels, measured at 12 time points over three years. Longitudinal and correlational analyses were performed using linear and polynomial regression models.ResultsNon-linear trends in oxytocin levels were identified, with polynomial regression revealing a significant quadratic term, suggesting a parabolic trend. Strong positive correlations were found between changes in oxytocin levels and YBOCS total, obsession, and compulsion scores.ConclusionThe findings suggest a significant non-linear evolution of oxytocin levels and a positive correlation with OCD symptom changes following BNST-DBS. Oxytocin levels could serve as a biomarker for DBS efficacy if this finding is replicated in larger studies. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-b745f362ff584f01a13f3348dd7b13752025-01-27T06:40:17ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.14737971473797Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCDJean-Baptiste Belge0Jean-Baptiste Belge1Vincent Geenen2Anne L. Salado3Bruno Kaschten4Didier Martin5Gabrielle Scantamburlo6Gabrielle Scantamburlo7Department of Psychiatry, Liège University Hospital, University of Liège, Liège, BelgiumPsycho-Neuro-Endocrinology Unit, University of Liège, Liège, BelgiumGIGA Research Institute, GIGA-Immunity, Inflammation and Infection (GIGA-I3), University of Liège, Liège, BelgiumDepartment of Neurosurgery, Liège University Hospital, University of Liège, Liège, BelgiumDepartment of Neurosurgery, Liège University Hospital, University of Liège, Liège, BelgiumDepartment of Neurosurgery, Liège University Hospital, University of Liège, Liège, BelgiumDepartment of Psychiatry, Liège University Hospital, University of Liège, Liège, BelgiumPsycho-Neuro-Endocrinology Unit, University of Liège, Liège, BelgiumIntroductionObsessive-compulsive disorder (OCD) is a challenging neuropsychiatric condition with a subset of patients remaining refractory to conventional treatments. Deep brain stimulation (DBS) of the bed nucleus of the stria terminalis (BNST) has shown promise for severe, treatment-resistant OCD. This case report examines the relationship between plasma oxytocin levels and OCD symptom severity following BNST-DBS.MethodsA 36-year-old patient with long-standing, treatment-resistant OCD underwent stereotactic implantation of DBS electrodes at the BNST. Postoperative assessments included OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and plasma oxytocin levels, measured at 12 time points over three years. Longitudinal and correlational analyses were performed using linear and polynomial regression models.ResultsNon-linear trends in oxytocin levels were identified, with polynomial regression revealing a significant quadratic term, suggesting a parabolic trend. Strong positive correlations were found between changes in oxytocin levels and YBOCS total, obsession, and compulsion scores.ConclusionThe findings suggest a significant non-linear evolution of oxytocin levels and a positive correlation with OCD symptom changes following BNST-DBS. Oxytocin levels could serve as a biomarker for DBS efficacy if this finding is replicated in larger studies.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1473797/fullDBS (deep brain stimulation)OCD (obsessive-compulsive disorder)oxytocinnon-linearneuromodulation |
| spellingShingle | Jean-Baptiste Belge Jean-Baptiste Belge Vincent Geenen Anne L. Salado Bruno Kaschten Didier Martin Gabrielle Scantamburlo Gabrielle Scantamburlo Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD Frontiers in Psychiatry DBS (deep brain stimulation) OCD (obsessive-compulsive disorder) oxytocin non-linear neuromodulation |
| title | Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD |
| title_full | Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD |
| title_fullStr | Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD |
| title_full_unstemmed | Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD |
| title_short | Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD |
| title_sort | case report non linear evolution of oxytocin informs ybocs changes post dbs of the bed nucleus of the stria terminalis for treatment resistant ocd |
| topic | DBS (deep brain stimulation) OCD (obsessive-compulsive disorder) oxytocin non-linear neuromodulation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1473797/full |
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