Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

Abstract Guben Xiezhuo decoction (GBXZD), a traditional Chinese medicine (TCM), shows promise in treating chronic kidney disease (CKD) by reducing renal fibrosis (RF). This study seeks to uncover the exact mechanism behind GBXZD’s therapeutic effects. This study identified 14 active components and 1...

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Bibliographic Details
Main Authors: Shutao Chen, Yue Liu, Liwei Zhu, Jingyi Wu, Ziyun Xu, Yingyu Zhang, Minggang Wei, Zhenfang Du, Sheng Qiang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Guben Xiezhuo decoction
Renal fibrosis
Network pharmacology
Bioinformatic
Online Access:https://doi.org/10.1038/s41598-025-16012-6
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