Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

Abstract Interleukin-15 (IL-15) is essential for the development and maintenance of natural killer (NK) cells. IL-15 activates STAT5 proteins, which can form dimers or tetramers. We previously found that NK cell numbers are decreased in Stat5a−Stat5b tetramer-deficient double knockin (DKI) mice, but...

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Bibliographic Details
Main Authors: Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01477-5
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