Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant
New-onset jaundice can be a manifestation of multiple pathologic processes including hemolysis, parenchymal liver disease, and cholestasis; the differential diagnosis is broad and requires a systematic approach. We report a case of a patient who presented with jaundice after starting minocycline for...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/672985 |
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| author | Talal Hilal R. Scott Morehead |
| author_facet | Talal Hilal R. Scott Morehead |
| author_sort | Talal Hilal |
| collection | DOAJ |
| description | New-onset jaundice can be a manifestation of multiple pathologic processes including hemolysis, parenchymal liver disease, and cholestasis; the differential diagnosis is broad and requires a systematic approach. We report a case of a patient who presented with jaundice after starting minocycline for the treatment of acne vulgaris and rapidly developed fulminant liver failure found to be due to Wilson’s disease. She also manifested severe Coomb’s negative hemolytic anemia and renal failure secondary to hepatorenal syndrome. As a bridge to liver transplant, she was successfully treated with plasmapheresis to decrease serum copper in addition to hemodialysis for acidosis and hyperkalemia. She was able to receive a liver and made a full recovery. The case highlights the use of plasmapheresis as an adjunctive treatment modality in cases of fulminant liver failure due to Wilson’s disease. |
| format | Article |
| id | doaj-art-b733c8ba5e0041c990488f0ba90fb7ba |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b733c8ba5e0041c990488f0ba90fb7ba2025-08-20T02:19:19ZengWileyCase Reports in Medicine1687-96271687-96352014-01-01201410.1155/2014/672985672985Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver TransplantTalal Hilal0R. Scott Morehead1Department of Internal Medicine, University of Kentucky College of Medicine, Charles T. Wethington Building 304B, 900 South Limestone Street, Lexington, KY 40536, USADepartment of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky College of Medicine, Kentucky Clinic L543, 740 South Limestone Street, Lexington, KY 40536, USANew-onset jaundice can be a manifestation of multiple pathologic processes including hemolysis, parenchymal liver disease, and cholestasis; the differential diagnosis is broad and requires a systematic approach. We report a case of a patient who presented with jaundice after starting minocycline for the treatment of acne vulgaris and rapidly developed fulminant liver failure found to be due to Wilson’s disease. She also manifested severe Coomb’s negative hemolytic anemia and renal failure secondary to hepatorenal syndrome. As a bridge to liver transplant, she was successfully treated with plasmapheresis to decrease serum copper in addition to hemodialysis for acidosis and hyperkalemia. She was able to receive a liver and made a full recovery. The case highlights the use of plasmapheresis as an adjunctive treatment modality in cases of fulminant liver failure due to Wilson’s disease.http://dx.doi.org/10.1155/2014/672985 |
| spellingShingle | Talal Hilal R. Scott Morehead Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant Case Reports in Medicine |
| title | Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant |
| title_full | Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant |
| title_fullStr | Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant |
| title_full_unstemmed | Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant |
| title_short | Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant |
| title_sort | fulminant wilson s disease managed with plasmapheresis as a bridge to liver transplant |
| url | http://dx.doi.org/10.1155/2014/672985 |
| work_keys_str_mv | AT talalhilal fulminantwilsonsdiseasemanagedwithplasmapheresisasabridgetolivertransplant AT rscottmorehead fulminantwilsonsdiseasemanagedwithplasmapheresisasabridgetolivertransplant |