IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although cytokines are critical for the inflammatory process, there are single findings concerning concentration of IL-17 in bullous diseases. The goal of this stu...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/967987 |
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| author | Agnieszka Zebrowska Malgorzata Wagrowska-Danilewicz Marian Danilewicz Olga Stasikowska-Kanicka Anna Cynkier Anna Sysa-Jedrzejowska Elzbieta Waszczykowska |
| author_facet | Agnieszka Zebrowska Malgorzata Wagrowska-Danilewicz Marian Danilewicz Olga Stasikowska-Kanicka Anna Cynkier Anna Sysa-Jedrzejowska Elzbieta Waszczykowska |
| author_sort | Agnieszka Zebrowska |
| collection | DOAJ |
| description | Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although cytokines are critical for the inflammatory process, there are single findings concerning concentration of IL-17 in bullous diseases. The goal of this study was to assess IL-17 expression in DH and BP patients. Skin biopsies were taken from 10 DH, 14 BP patients and from 10 healthy subjects. The localization and expression of IL-17 was studied by immunohistochemistry and the serum concentration was measured by immunoassays. Expression of IL-17 in the epidermis and in influxed cells in dermis was detected in skin biopsies. Expression of IL-17 was statistically higher in epidermis and infiltration cells in specimens from BP than from DH patients. Examined interleukin expression was detected in perilesional skin of all patients but it was much lower than in lesional skin. The expression of IL-17 was not observed in biopsies from healthy people. Serum level of IL-17 was statistically higher in BP and DH groups as compared to control group. Our results provide the evidence that IL-17 may play an essential role in activating and recruiting eosinophils and neutrophils, which ultimately contribute to the tissue damage in DH and BP. |
| format | Article |
| id | doaj-art-b7319d931d104118a60c0744ad2e2260 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b7319d931d104118a60c0744ad2e22602025-02-03T06:01:30ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/967987967987IL-17 Expression in Dermatitis Herpetiformis and Bullous PemphigoidAgnieszka Zebrowska0Malgorzata Wagrowska-Danilewicz1Marian Danilewicz2Olga Stasikowska-Kanicka3Anna Cynkier4Anna Sysa-Jedrzejowska5Elzbieta Waszczykowska6Department of Dermatology and Venereology, Medical University of Lodz, 5 Krzemieniecka Street, 94-017 Lodz, PolandLaboratory of Nephropathology of Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, PolandLaboratory of Nephropathology of Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, PolandLaboratory of Nephropathology of Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, 5 Krzemieniecka Street, 94-017 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, 5 Krzemieniecka Street, 94-017 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, 5 Krzemieniecka Street, 94-017 Lodz, PolandDermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although cytokines are critical for the inflammatory process, there are single findings concerning concentration of IL-17 in bullous diseases. The goal of this study was to assess IL-17 expression in DH and BP patients. Skin biopsies were taken from 10 DH, 14 BP patients and from 10 healthy subjects. The localization and expression of IL-17 was studied by immunohistochemistry and the serum concentration was measured by immunoassays. Expression of IL-17 in the epidermis and in influxed cells in dermis was detected in skin biopsies. Expression of IL-17 was statistically higher in epidermis and infiltration cells in specimens from BP than from DH patients. Examined interleukin expression was detected in perilesional skin of all patients but it was much lower than in lesional skin. The expression of IL-17 was not observed in biopsies from healthy people. Serum level of IL-17 was statistically higher in BP and DH groups as compared to control group. Our results provide the evidence that IL-17 may play an essential role in activating and recruiting eosinophils and neutrophils, which ultimately contribute to the tissue damage in DH and BP.http://dx.doi.org/10.1155/2013/967987 |
| spellingShingle | Agnieszka Zebrowska Malgorzata Wagrowska-Danilewicz Marian Danilewicz Olga Stasikowska-Kanicka Anna Cynkier Anna Sysa-Jedrzejowska Elzbieta Waszczykowska IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid Mediators of Inflammation |
| title | IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid |
| title_full | IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid |
| title_fullStr | IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid |
| title_full_unstemmed | IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid |
| title_short | IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid |
| title_sort | il 17 expression in dermatitis herpetiformis and bullous pemphigoid |
| url | http://dx.doi.org/10.1155/2013/967987 |
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