Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black
Background Exposure to carbon black can induce respiratory toxicity, leading to tissue remodeling, inflammation, and fibrosis. Curcumin, a compound from Curcuma longa, has been shown to exert protective effects on lung tissue by inhibiting cell proliferation and reducing alveolar epithelial thicken...
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School of Veterinary Medicine and Biomedical Sciences, IPB University
2025-01-01
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| Series: | Current Biomedicine |
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| Online Access: | https://journal.ipb.ac.id/index.php/currbiomed/article/view/57771 |
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| author | El Roy Achmad Rahmaniabdi Imam Mustofa Eka Pramyrtha Hestianah Widjiati Widjiati Rochmah Kurnijasanti Hani Plumeriastuti |
| author_facet | El Roy Achmad Rahmaniabdi Imam Mustofa Eka Pramyrtha Hestianah Widjiati Widjiati Rochmah Kurnijasanti Hani Plumeriastuti |
| author_sort | El Roy Achmad Rahmaniabdi |
| collection | DOAJ |
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Background Exposure to carbon black can induce respiratory toxicity, leading to tissue remodeling, inflammation, and fibrosis. Curcumin, a compound from Curcuma longa, has been shown to exert protective effects on lung tissue by inhibiting cell proliferation and reducing alveolar epithelial thickening and inflammatory responses.
Objective This study aimed to evaluate the effect of nanocurcumin administration on alveolar septal thickness and fibrosis in the lungs of rats (Rattus norvegicus) exposed to carbon black.
Methods Thirty female rats were divided into five groups: the negative control group (K-) received distilled water without carbon black exposure; the positive control group (K+) received distilled water and was exposed to carbon black at a dose of 1064 mg/m³ for 6 hours; and treatment groups P1, P2, and P3 received nanocurcumin at doses of 50, 100, and 200 mg/kg body weight, respectively, along with carbon black exposure at a dose of 1064 mg/m³ for 6 hours/day over 30 days.
Results Alveolar septal thickness and fibrosis in the P1, P2, and P3 groups showed significant reductions (P<0.05) compared to the K+ group. Notably, groups P2 and P3 exhibited similar alveolar septal thickness to the K- group, with statistically lower (P<0.05) fibrosis levels than P1 but not significantly different from K- (P>0.05).
Conclusion Nanocurcumin administration demonstrates potential in mitigating alveolar septal thickening and fibrosis in rat lungs subjected to carbon black exposure, suggesting a protective role against pulmonary damage from particulate matter.
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| format | Article |
| id | doaj-art-b729ca64b4394683bb953d27c0d59802 |
| institution | Kabale University |
| issn | 2962-8490 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | School of Veterinary Medicine and Biomedical Sciences, IPB University |
| record_format | Article |
| series | Current Biomedicine |
| spelling | doaj-art-b729ca64b4394683bb953d27c0d598022025-01-22T18:19:50ZengSchool of Veterinary Medicine and Biomedical Sciences, IPB UniversityCurrent Biomedicine2962-84902025-01-013110.29244/currbiomed.3.1.38Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black El Roy Achmad Rahmaniabdi0 Imam Mustofa1 Eka Pramyrtha Hestianah2 Widjiati Widjiati3 Rochmah Kurnijasanti4 Hani Plumeriastuti5Study Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia Background Exposure to carbon black can induce respiratory toxicity, leading to tissue remodeling, inflammation, and fibrosis. Curcumin, a compound from Curcuma longa, has been shown to exert protective effects on lung tissue by inhibiting cell proliferation and reducing alveolar epithelial thickening and inflammatory responses. Objective This study aimed to evaluate the effect of nanocurcumin administration on alveolar septal thickness and fibrosis in the lungs of rats (Rattus norvegicus) exposed to carbon black. Methods Thirty female rats were divided into five groups: the negative control group (K-) received distilled water without carbon black exposure; the positive control group (K+) received distilled water and was exposed to carbon black at a dose of 1064 mg/m³ for 6 hours; and treatment groups P1, P2, and P3 received nanocurcumin at doses of 50, 100, and 200 mg/kg body weight, respectively, along with carbon black exposure at a dose of 1064 mg/m³ for 6 hours/day over 30 days. Results Alveolar septal thickness and fibrosis in the P1, P2, and P3 groups showed significant reductions (P<0.05) compared to the K+ group. Notably, groups P2 and P3 exhibited similar alveolar septal thickness to the K- group, with statistically lower (P<0.05) fibrosis levels than P1 but not significantly different from K- (P>0.05). Conclusion Nanocurcumin administration demonstrates potential in mitigating alveolar septal thickening and fibrosis in rat lungs subjected to carbon black exposure, suggesting a protective role against pulmonary damage from particulate matter. https://journal.ipb.ac.id/index.php/currbiomed/article/view/57771alveolar septal thickeningcarbon black exposureCurcuma longafibrosisnanocurcumin |
| spellingShingle | El Roy Achmad Rahmaniabdi Imam Mustofa Eka Pramyrtha Hestianah Widjiati Widjiati Rochmah Kurnijasanti Hani Plumeriastuti Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black Current Biomedicine alveolar septal thickening carbon black exposure Curcuma longa fibrosis nanocurcumin |
| title | Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black |
| title_full | Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black |
| title_fullStr | Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black |
| title_full_unstemmed | Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black |
| title_short | Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black |
| title_sort | effect of nanocurcumin curcuma longa on lung histopathology in rats exposed to carbon black |
| topic | alveolar septal thickening carbon black exposure Curcuma longa fibrosis nanocurcumin |
| url | https://journal.ipb.ac.id/index.php/currbiomed/article/view/57771 |
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