Synergistic neurotrophic effects of piracetam and thiotriazoline
The paper considers the synergy between the nootropic drug piracetam and the metabolic agent thiotriazoline that maintains energy metabolism and survival of neurons and other types of cells. Piracetam, a nootropic drug, a chemical pyrrolidone derivative, is used in neurological, psychiatric, and nar...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2016-03-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/588 |
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| author | O. A. Gromova I. Yu. Torshin A. V. Pronin A. Yu. Volkov |
| author_facet | O. A. Gromova I. Yu. Torshin A. V. Pronin A. Yu. Volkov |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | The paper considers the synergy between the nootropic drug piracetam and the metabolic agent thiotriazoline that maintains energy metabolism and survival of neurons and other types of cells. Piracetam, a nootropic drug, a chemical pyrrolidone derivative, is used in neurological, psychiatric, and narcological practice. There is evidence on the positive effect of piracetam in elderly and senile patients with coronary heart disease. This drug is supposed to stimulate redox processes, to enhance glucose utilization, and to improve regional blood flow in the ischemic brain regions. Due to its action, the drug activates glycolytic processes and elevates ATP concentrations in brain tissue. Thiotriazoline is a compound that has antioxidant, anti-ischemic properties. The co-administration of piracetam and thiothriazoline is an innovation area in the treatment of stroke and other brain damages, especially in insulin resistance and high blood glucose levels. The paper considers the neurobiological properties of thiotriazoline and piracetam, which synergistically exert neuroprotective and neurotrophic effects. |
| format | Article |
| id | doaj-art-b725cfc8f3ee453eb8c6fb340ab6f35e |
| institution | OA Journals |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| publishDate | 2016-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj-art-b725cfc8f3ee453eb8c6fb340ab6f35e2025-08-20T02:16:15ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422016-03-0181868910.14412/2074-2711-2016-1-86-89543Synergistic neurotrophic effects of piracetam and thiotriazolineO. A. Gromova0I. Yu. Torshin1A. V. Pronin2A. Yu. Volkov3Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia 8, Sheremetevsky Passage., Ivanovo 153000 Russian Satellite Neurobiology Center, Trace Element Institute for UNESCO, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia 1, Ostrovityanov St., Moscow 117997Russian Satellite Neurobiology Center, Trace Element Institute for UNESCO, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia 1, Ostrovityanov St., Moscow 117997Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia 8, Sheremetevsky Passage., Ivanovo 153000 Russian Satellite Neurobiology Center, Trace Element Institute for UNESCO, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia 1, Ostrovityanov St., Moscow 117997Russian Satellite Neurobiology Center, Trace Element Institute for UNESCO, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia 1, Ostrovityanov St., Moscow 117997The paper considers the synergy between the nootropic drug piracetam and the metabolic agent thiotriazoline that maintains energy metabolism and survival of neurons and other types of cells. Piracetam, a nootropic drug, a chemical pyrrolidone derivative, is used in neurological, psychiatric, and narcological practice. There is evidence on the positive effect of piracetam in elderly and senile patients with coronary heart disease. This drug is supposed to stimulate redox processes, to enhance glucose utilization, and to improve regional blood flow in the ischemic brain regions. Due to its action, the drug activates glycolytic processes and elevates ATP concentrations in brain tissue. Thiotriazoline is a compound that has antioxidant, anti-ischemic properties. The co-administration of piracetam and thiothriazoline is an innovation area in the treatment of stroke and other brain damages, especially in insulin resistance and high blood glucose levels. The paper considers the neurobiological properties of thiotriazoline and piracetam, which synergistically exert neuroprotective and neurotrophic effects.https://nnp.ima-press.net/nnp/article/view/588piracetamthiotrizolinethiacetamneuroprotectionneurotrophic effect |
| spellingShingle | O. A. Gromova I. Yu. Torshin A. V. Pronin A. Yu. Volkov Synergistic neurotrophic effects of piracetam and thiotriazoline Неврология, нейропсихиатрия, психосоматика piracetam thiotrizoline thiacetam neuroprotection neurotrophic effect |
| title | Synergistic neurotrophic effects of piracetam and thiotriazoline |
| title_full | Synergistic neurotrophic effects of piracetam and thiotriazoline |
| title_fullStr | Synergistic neurotrophic effects of piracetam and thiotriazoline |
| title_full_unstemmed | Synergistic neurotrophic effects of piracetam and thiotriazoline |
| title_short | Synergistic neurotrophic effects of piracetam and thiotriazoline |
| title_sort | synergistic neurotrophic effects of piracetam and thiotriazoline |
| topic | piracetam thiotrizoline thiacetam neuroprotection neurotrophic effect |
| url | https://nnp.ima-press.net/nnp/article/view/588 |
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