AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression

AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression

Abstract The androgen receptor (AR) usually drives prostate cancer cell growth, yet its role in immune cells such as tumour-associated macrophages (TAMs), remains unclear. We find that macrophages co-expressing AR and triggering receptor expressed on myeloid cells-2 (TREM2) exhibiting potent immunos...

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Bibliographic Details
Main Authors: Qiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang, Guanmin Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62381-x
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