Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review
Background: Soft tissue undifferentiated sarcomas (STUS) are an ultra-rare and heterogenous group of mesenchymal neoplasms often lacking known genetic abnormalities with a marked vulnerability towards intensive therapy such as invasive surgery and high dose chemotherapy. Despite aggressive treatment...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-02-01
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| Series: | Acta Oncologica |
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| Online Access: | https://medicaljournalssweden.se/actaoncologica/article/view/42162 |
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| author | Aleksandra Stanio Jakub Czarny Sandra Rutkowska Katarzyna Adamczewska-Wawrzynowicz Łukasz Młynarczyk Agnieszka Stróżyk Katarzyna Jończyk-Potoczna Alicja Bartkowska-Śniatkowska Jacek Wachowiak Katarzyna Derwich Olga Zając-Spychała |
| author_facet | Aleksandra Stanio Jakub Czarny Sandra Rutkowska Katarzyna Adamczewska-Wawrzynowicz Łukasz Młynarczyk Agnieszka Stróżyk Katarzyna Jończyk-Potoczna Alicja Bartkowska-Śniatkowska Jacek Wachowiak Katarzyna Derwich Olga Zając-Spychała |
| author_sort | Aleksandra Stanio |
| collection | DOAJ |
| description | Background: Soft tissue undifferentiated sarcomas (STUS) are an ultra-rare and heterogenous group of mesenchymal neoplasms often lacking known genetic abnormalities with a marked vulnerability towards intensive therapy such as invasive surgery and high dose chemotherapy. Despite aggressive treatment, they are usually associated with dismal outcomes.
Case presentation: Here we describe two cases of STUS in 3-week-old and 3-month-old infants localized on the neck and the trunk area.
Discussion: In both cases, the malignancy had a fatal outcome due to the toxicity of intensive therapy in one case and the progression of the disease in the other. The purpose of this report is to discuss the clinical challenges of managing infancy-related STUS such as limited treatment options and poor prognosis.
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| format | Article |
| id | doaj-art-b71e379311df49f5b3c4bd37e206e454 |
| institution | Kabale University |
| issn | 1651-226X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Oncologica |
| spelling | doaj-art-b71e379311df49f5b3c4bd37e206e4542025-02-11T07:08:47ZengMedical Journals SwedenActa Oncologica1651-226X2025-02-016410.2340/1651-226X.2025.42162Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature reviewAleksandra Stanio0Jakub Czarny1Sandra Rutkowska2Katarzyna Adamczewska-Wawrzynowicz3Łukasz Młynarczyk4Agnieszka Stróżyk5Katarzyna Jończyk-Potoczna6Alicja Bartkowska-Śniatkowska7Jacek Wachowiak8Katarzyna Derwich9Olga Zając-Spychała10Student Scientific Circle, Poznan University of Medical Sciences, PolandStudent Scientific Circle, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Radiology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, PolandBackground: Soft tissue undifferentiated sarcomas (STUS) are an ultra-rare and heterogenous group of mesenchymal neoplasms often lacking known genetic abnormalities with a marked vulnerability towards intensive therapy such as invasive surgery and high dose chemotherapy. Despite aggressive treatment, they are usually associated with dismal outcomes. Case presentation: Here we describe two cases of STUS in 3-week-old and 3-month-old infants localized on the neck and the trunk area. Discussion: In both cases, the malignancy had a fatal outcome due to the toxicity of intensive therapy in one case and the progression of the disease in the other. The purpose of this report is to discuss the clinical challenges of managing infancy-related STUS such as limited treatment options and poor prognosis. https://medicaljournalssweden.se/actaoncologica/article/view/42162undifferentiated sarcomainfancyprogressionaggressive chemotherapychemotherapy toxicity |
| spellingShingle | Aleksandra Stanio Jakub Czarny Sandra Rutkowska Katarzyna Adamczewska-Wawrzynowicz Łukasz Młynarczyk Agnieszka Stróżyk Katarzyna Jończyk-Potoczna Alicja Bartkowska-Śniatkowska Jacek Wachowiak Katarzyna Derwich Olga Zając-Spychała Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review Acta Oncologica undifferentiated sarcoma infancy progression aggressive chemotherapy chemotherapy toxicity |
| title | Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review |
| title_full | Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review |
| title_fullStr | Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review |
| title_full_unstemmed | Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review |
| title_short | Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review |
| title_sort | infantile undifferentiated sarcomas a diagnostic and therapeutic challenge two case reports and literature review |
| topic | undifferentiated sarcoma infancy progression aggressive chemotherapy chemotherapy toxicity |
| url | https://medicaljournalssweden.se/actaoncologica/article/view/42162 |
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