Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk

Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk

IntroductionPost-Traumatic Stress Disorder (PTSD) entails behavioral changes with increased risk of suicide, and there is no consensus on the preferred antidepressants for treatment of those PTSD patients who are at elevated risk for suicide.MethodsWe conducted a clinical trial emulation study compa...

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Bibliographic Details
Main Authors: Oshin Miranda, Xiguang Qi, M. Daniel Brannock, Ryan Whitworth, Thomas Kosten, Neal David Ryan, Gretchen L. Haas, Levent Kirisci, LiRong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Psychiatry
Subjects:
social determinants of health
post-tramatic stress disorder
suicide-related behavior
antidepressant
clinical trial emulation
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1526488/full
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