Depressed mood affects the process of biological aging, analyses from the NHANES dataset
BackgroundDepressive mood may influence biological aging and the difference (δ-age) between biological age (BA) and chronological age (CA). This study explores the relationship between depressive mood and whole-body delta age (δ-age).MethodsA total of 7,383 U.S. adults were selected from the Nationa...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2025.1516664/full |
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| author | Yuan Tian Yuan Tian Qiao Lu Qiao Lu Jing Li Jing Li Xiaobo Zhou Xiaobo Zhou Luyao Wang Luyao Wang Xuemei Zhong Xuemei Zhong Yiping Luo Yiping Luo |
| author_facet | Yuan Tian Yuan Tian Qiao Lu Qiao Lu Jing Li Jing Li Xiaobo Zhou Xiaobo Zhou Luyao Wang Luyao Wang Xuemei Zhong Xuemei Zhong Yiping Luo Yiping Luo |
| author_sort | Yuan Tian |
| collection | DOAJ |
| description | BackgroundDepressive mood may influence biological aging and the difference (δ-age) between biological age (BA) and chronological age (CA). This study explores the relationship between depressive mood and whole-body delta age (δ-age).MethodsA total of 7,383 U.S. adults were selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. Depressed mood was evaluated using PHQ-9 scores. Biological age (BA) was estimated based on circulating biomarkers, and the calculated delta age (δ-age) was validated through a generalized linear regression analysis.ResultsAfter adjusting for confounding variables, logistic regression analysis demonstrated a significant association between elevated depressive symptoms and accelerated biological aging. The restricted cubic splines (RCS) results further indicated a positive dose-response relationship between depression scale scores and the risk of biological aging. Additionally, the weighted quantile sum regression (WQS) findings revealed a positive, though non-significant, trend linking depressive mood to the risk of biological aging. Notably, overeating and low self-perception emerged as the most significant contributors to the scores on the Patient Health Questionnaire-9 (PHQ-9) scale.ConclusionDepressive symptoms are linked to accelerated biological aging. Thus, interventions aimed at improving mood may help slow biological aging and contribute to delaying the aging process. |
| format | Article |
| id | doaj-art-b7177bc7412c4e1fa8a3326da0e2173f |
| institution | Kabale University |
| issn | 2673-6217 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj-art-b7177bc7412c4e1fa8a3326da0e2173f2025-08-20T03:33:14ZengFrontiers Media S.A.Frontiers in Aging2673-62172025-07-01610.3389/fragi.2025.15166641516664Depressed mood affects the process of biological aging, analyses from the NHANES datasetYuan Tian0Yuan Tian1Qiao Lu2Qiao Lu3Jing Li4Jing Li5Xiaobo Zhou6Xiaobo Zhou7Luyao Wang8Luyao Wang9Xuemei Zhong10Xuemei Zhong11Yiping Luo12Yiping Luo13Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaSichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaSichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaSichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaSichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaSichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaSichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, ChinaBackgroundDepressive mood may influence biological aging and the difference (δ-age) between biological age (BA) and chronological age (CA). This study explores the relationship between depressive mood and whole-body delta age (δ-age).MethodsA total of 7,383 U.S. adults were selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. Depressed mood was evaluated using PHQ-9 scores. Biological age (BA) was estimated based on circulating biomarkers, and the calculated delta age (δ-age) was validated through a generalized linear regression analysis.ResultsAfter adjusting for confounding variables, logistic regression analysis demonstrated a significant association between elevated depressive symptoms and accelerated biological aging. The restricted cubic splines (RCS) results further indicated a positive dose-response relationship between depression scale scores and the risk of biological aging. Additionally, the weighted quantile sum regression (WQS) findings revealed a positive, though non-significant, trend linking depressive mood to the risk of biological aging. Notably, overeating and low self-perception emerged as the most significant contributors to the scores on the Patient Health Questionnaire-9 (PHQ-9) scale.ConclusionDepressive symptoms are linked to accelerated biological aging. Thus, interventions aimed at improving mood may help slow biological aging and contribute to delaying the aging process.https://www.frontiersin.org/articles/10.3389/fragi.2025.1516664/fulldepressed moodbiological agingagingactual ageNHANES |
| spellingShingle | Yuan Tian Yuan Tian Qiao Lu Qiao Lu Jing Li Jing Li Xiaobo Zhou Xiaobo Zhou Luyao Wang Luyao Wang Xuemei Zhong Xuemei Zhong Yiping Luo Yiping Luo Depressed mood affects the process of biological aging, analyses from the NHANES dataset Frontiers in Aging depressed mood biological aging aging actual age NHANES |
| title | Depressed mood affects the process of biological aging, analyses from the NHANES dataset |
| title_full | Depressed mood affects the process of biological aging, analyses from the NHANES dataset |
| title_fullStr | Depressed mood affects the process of biological aging, analyses from the NHANES dataset |
| title_full_unstemmed | Depressed mood affects the process of biological aging, analyses from the NHANES dataset |
| title_short | Depressed mood affects the process of biological aging, analyses from the NHANES dataset |
| title_sort | depressed mood affects the process of biological aging analyses from the nhanes dataset |
| topic | depressed mood biological aging aging actual age NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2025.1516664/full |
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