Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease

Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease

The immune system plays a crucial role in the pathogenesis of neurodegenerative diseases. Here, we explored whether blood immune cell profiles are already altered in healthy individuals with a genetic predisposition to amyotrophic lateral sclerosis (ALS) or Alzheimer’s disease (AD). Using multicolor...

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Bibliographic Details
Main Authors: Laura Deecke, Olena Ohlei, David Goldeck, Jan Homann, Sarah Toepfer, Ilja Demuth, Lars Bertram, Graham Pawelec, Christina M. Lill
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
immune system
immune cell
neurodegeneration
polygenic risk score
disease prediction
Online Access:https://www.mdpi.com/2073-4409/14/4/250
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