The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans
The presented data have been obtained as a result of a comprehensive experimental study of separately sulfated glycosaminoglycans (sGAG) using in vitro stromal cell cultures of the sheep bone marrow and the bone collagen impregnated with sGAG on a rat heterotopic implantation model and on a rabbit o...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2016-01-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/2 |
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| author | M. V. Lekishvili M. G. Vasiliev |
| author_facet | M. V. Lekishvili M. G. Vasiliev |
| author_sort | M. V. Lekishvili |
| collection | DOAJ |
| description | The presented data have been obtained as a result of a comprehensive experimental study of separately sulfated glycosaminoglycans (sGAG) using in vitro stromal cell cultures of the sheep bone marrow and the bone collagen impregnated with sGAG on a rat heterotopic implantation model and on a rabbit orthotopic implantation model.We have not obtained credible evidence that would support a sGAG stimulating effect on cell and tissue regeneration. The designed biocomposite material based on sGAG-impregnated allogenic bone collagen was used in 54 patients with various bone diseases.Surgical treatment using developed material demonstrated a positive effect on outcomes in 48 patients (89%) that was regarded as a good result. |
| format | Article |
| id | doaj-art-b713fed0bee747ee91e187febf604e79 |
| institution | DOAJ |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-b713fed0bee747ee91e187febf604e792025-08-20T02:55:45ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092016-01-010110172The properties of osteoplastic materials impregnated with sulfated glycosaminoglycansM. V. Lekishvili0M. G. Vasiliev1Central Research Institute of Traumatology and Orthopaedics n.a. N.N. PriorovCentral Research Institute of Traumatology and Orthopaedics n.a. N.N. PriorovThe presented data have been obtained as a result of a comprehensive experimental study of separately sulfated glycosaminoglycans (sGAG) using in vitro stromal cell cultures of the sheep bone marrow and the bone collagen impregnated with sGAG on a rat heterotopic implantation model and on a rabbit orthotopic implantation model.We have not obtained credible evidence that would support a sGAG stimulating effect on cell and tissue regeneration. The designed biocomposite material based on sGAG-impregnated allogenic bone collagen was used in 54 patients with various bone diseases.Surgical treatment using developed material demonstrated a positive effect on outcomes in 48 patients (89%) that was regarded as a good result.https://www.jtransplantologiya.ru/jour/article/view/2osteoplastic materialssulfated glycosaminoglycansexperiment |
| spellingShingle | M. V. Lekishvili M. G. Vasiliev The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans Трансплантология (Москва) osteoplastic materials sulfated glycosaminoglycans experiment |
| title | The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans |
| title_full | The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans |
| title_fullStr | The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans |
| title_full_unstemmed | The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans |
| title_short | The properties of osteoplastic materials impregnated with sulfated glycosaminoglycans |
| title_sort | properties of osteoplastic materials impregnated with sulfated glycosaminoglycans |
| topic | osteoplastic materials sulfated glycosaminoglycans experiment |
| url | https://www.jtransplantologiya.ru/jour/article/view/2 |
| work_keys_str_mv | AT mvlekishvili thepropertiesofosteoplasticmaterialsimpregnatedwithsulfatedglycosaminoglycans AT mgvasiliev thepropertiesofosteoplasticmaterialsimpregnatedwithsulfatedglycosaminoglycans AT mvlekishvili propertiesofosteoplasticmaterialsimpregnatedwithsulfatedglycosaminoglycans AT mgvasiliev propertiesofosteoplasticmaterialsimpregnatedwithsulfatedglycosaminoglycans |