Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan
An increase in the number of herpes zoster patients has been reported since universal varicella immunization was introduced, perhaps because of reduced opportunities for varicella patients to experience the natural booster effect caused by reexposure. We investigated recent trends of varicella zost...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2024-12-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/30/12/24-0538_article |
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| author | Ayami Yoshikane Hiroki Miura Sayuri Shima Masaaki Matsunaga Soichiro Ishimaru Yuki Higashimoto Yoshiki Kawamura Kei Kozawa Akiko Yoshikawa Akihiro Ueda Atsuhiko Ota Hirohisa Watanabe Tatsuro Mutoh Tetsushi Yoshikawa |
| author_facet | Ayami Yoshikane Hiroki Miura Sayuri Shima Masaaki Matsunaga Soichiro Ishimaru Yuki Higashimoto Yoshiki Kawamura Kei Kozawa Akiko Yoshikawa Akihiro Ueda Atsuhiko Ota Hirohisa Watanabe Tatsuro Mutoh Tetsushi Yoshikawa |
| author_sort | Ayami Yoshikane |
| collection | DOAJ |
| description |
An increase in the number of herpes zoster patients has been reported since universal varicella immunization was introduced, perhaps because of reduced opportunities for varicella patients to experience the natural booster effect caused by reexposure. We investigated recent trends of varicella zoster virus (VZV)–related central nervous system (CNS) infections at a university hospital in Japan. We enrolled patients with suspected CNS infection during 2013–2022 and tested cerebrospinal fluid samples by real-time PCR for DNA from 7 human herpesviruses. VZV DNA was the most commonly detected in 62 (10.2%) of 615 patients. Kulldorff’s circular spatial scan statistics demonstrated a significant temporal cluster of patients with VZV-related CNS infections during 2019–2022 (p = 0.008). Among persons with such infections, the percentage with aseptic meningitis was significantly higher during 2019–2022 (86.8%), when the temporal cluster of cases occurred, than during 2013–2018 (50.0%) (p = 0.0029).
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| format | Article |
| id | doaj-art-b70c6d99f7e541dda02c08e0cdac91b9 |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-b70c6d99f7e541dda02c08e0cdac91b92025-08-20T02:05:35ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592024-12-0130122476248210.3201/eid3012.240538Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, JapanAyami YoshikaneHiroki MiuraSayuri ShimaMasaaki MatsunagaSoichiro IshimaruYuki HigashimotoYoshiki KawamuraKei KozawaAkiko YoshikawaAkihiro UedaAtsuhiko OtaHirohisa WatanabeTatsuro MutohTetsushi Yoshikawa An increase in the number of herpes zoster patients has been reported since universal varicella immunization was introduced, perhaps because of reduced opportunities for varicella patients to experience the natural booster effect caused by reexposure. We investigated recent trends of varicella zoster virus (VZV)–related central nervous system (CNS) infections at a university hospital in Japan. We enrolled patients with suspected CNS infection during 2013–2022 and tested cerebrospinal fluid samples by real-time PCR for DNA from 7 human herpesviruses. VZV DNA was the most commonly detected in 62 (10.2%) of 615 patients. Kulldorff’s circular spatial scan statistics demonstrated a significant temporal cluster of patients with VZV-related CNS infections during 2019–2022 (p = 0.008). Among persons with such infections, the percentage with aseptic meningitis was significantly higher during 2019–2022 (86.8%), when the temporal cluster of cases occurred, than during 2013–2018 (50.0%) (p = 0.0029). https://wwwnc.cdc.gov/eid/article/30/12/24-0538_articlevirusescentral nervous system infectionvaricella zoster virusVZVreal-time PCRJapan |
| spellingShingle | Ayami Yoshikane Hiroki Miura Sayuri Shima Masaaki Matsunaga Soichiro Ishimaru Yuki Higashimoto Yoshiki Kawamura Kei Kozawa Akiko Yoshikawa Akihiro Ueda Atsuhiko Ota Hirohisa Watanabe Tatsuro Mutoh Tetsushi Yoshikawa Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan Emerging Infectious Diseases viruses central nervous system infection varicella zoster virus VZV real-time PCR Japan |
| title | Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan |
| title_full | Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan |
| title_fullStr | Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan |
| title_full_unstemmed | Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan |
| title_short | Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan |
| title_sort | increase in adult patients with varicella zoster virus related central nervous system infections japan |
| topic | viruses central nervous system infection varicella zoster virus VZV real-time PCR Japan |
| url | https://wwwnc.cdc.gov/eid/article/30/12/24-0538_article |
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