Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents
A series of benzamide substituted Mannich bases (1–7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/732141 |
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| author | Suman Bala Neha Sharma Anu Kajal Sunil Kamboj |
| author_facet | Suman Bala Neha Sharma Anu Kajal Sunil Kamboj |
| author_sort | Suman Bala |
| collection | DOAJ |
| description | A series of benzamide substituted Mannich bases (1–7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. The compounds 5, 6, and 7 were found to be the most active antibacterial agents among all the synthesized compounds. The physicochemical similarity of the compounds with standard drugs was assessed by calculating various physicochemical properties using software programs. The percent similarity of synthesized compounds was found to be good and compound 1 was found to have higher percentage of similarity. The compounds were subjected to QSAR by multilinear regression using Analyze it version 3.0 software, and four statistically sound models were developed with R2 (0.963–0.997), Radj2 (0.529–0.982), and Q2 (0.998–0.999) with good F (2.35–65.56) values. |
| format | Article |
| id | doaj-art-b70b02a026904f29ab70e0871e7e1ddf |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b70b02a026904f29ab70e0871e7e1ddf2025-02-03T06:44:38ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/732141732141Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial AgentsSuman Bala0Neha Sharma1Anu Kajal2Sunil Kamboj3M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaM. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaM. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaM. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, IndiaA series of benzamide substituted Mannich bases (1–7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. The compounds 5, 6, and 7 were found to be the most active antibacterial agents among all the synthesized compounds. The physicochemical similarity of the compounds with standard drugs was assessed by calculating various physicochemical properties using software programs. The percent similarity of synthesized compounds was found to be good and compound 1 was found to have higher percentage of similarity. The compounds were subjected to QSAR by multilinear regression using Analyze it version 3.0 software, and four statistically sound models were developed with R2 (0.963–0.997), Radj2 (0.529–0.982), and Q2 (0.998–0.999) with good F (2.35–65.56) values.http://dx.doi.org/10.1155/2014/732141 |
| spellingShingle | Suman Bala Neha Sharma Anu Kajal Sunil Kamboj Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents The Scientific World Journal |
| title | Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents |
| title_full | Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents |
| title_fullStr | Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents |
| title_full_unstemmed | Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents |
| title_short | Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents |
| title_sort | design synthesis characterization and computational studies on benzamide substituted mannich bases as novel potential antibacterial agents |
| url | http://dx.doi.org/10.1155/2014/732141 |
| work_keys_str_mv | AT sumanbala designsynthesischaracterizationandcomputationalstudiesonbenzamidesubstitutedmannichbasesasnovelpotentialantibacterialagents AT nehasharma designsynthesischaracterizationandcomputationalstudiesonbenzamidesubstitutedmannichbasesasnovelpotentialantibacterialagents AT anukajal designsynthesischaracterizationandcomputationalstudiesonbenzamidesubstitutedmannichbasesasnovelpotentialantibacterialagents AT sunilkamboj designsynthesischaracterizationandcomputationalstudiesonbenzamidesubstitutedmannichbasesasnovelpotentialantibacterialagents |