Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats
This study aimed at assessing the in-vivo effect of Vitamin C on liver enzymes and some endogenous antioxidants in paracetamol-induced model of liver toxicity on Wistar rats. The rats were grouped into four groups of five animals each; groups 1 and 2 were control (positive and negative), while grou...
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| Format: | Article |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2019-08-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.Ajol.Info/index.php/jasem/article/view/188785 |
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| author | E.G. Moke K.K. Anachuna P.O. Onyilo M. Emosivbe |
| author_facet | E.G. Moke K.K. Anachuna P.O. Onyilo M. Emosivbe |
| author_sort | E.G. Moke |
| collection | DOAJ |
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This study aimed at assessing the in-vivo effect of Vitamin C on liver enzymes and some endogenous antioxidants in paracetamol-induced model of liver toxicity on Wistar rats. The rats were grouped into four groups of five animals each; groups 1 and 2 were control (positive and negative), while group 3 and 4 received vitamin C 500 mg/kg and silymarin 100 mg/kg respectively. Dosing was oral and daily for 6 days according to their body weights. All the animals except the positive control group (Group 1) were administered paracetamol 3 g/kg on the 7th day, and then observed for 24 hours before sample collection for biochemical indices and liver histological studies. Paracetamol caused a significant (p<0.05) increase in liver enzymes, significant (p<0.05) decrease in antioxidant enzymes, and necrosis in liver tissues when compared to the control. Administration of 500 mg/kg Vitamin C prior to induction of liver damage by PCM resulted in significant (p<0.05) decreased liver enzyme and well as an increase in the antioxidant enzymes. Pre-treatment of the animals with vitamin C showed a reversal of the toxic effect of paracetamol on the rats.
Keywords: Vitamin C, liver enzymes, paracetamol, toxicity.
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| format | Article |
| id | doaj-art-b7096bf938584d3d90844bc0399b2f10 |
| institution | Kabale University |
| issn | 2659-1502 2659-1499 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj-art-b7096bf938584d3d90844bc0399b2f102025-02-08T19:51:31ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992019-08-01237Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar RatsE.G. MokeK.K. AnachunaP.O. OnyiloM. Emosivbe This study aimed at assessing the in-vivo effect of Vitamin C on liver enzymes and some endogenous antioxidants in paracetamol-induced model of liver toxicity on Wistar rats. The rats were grouped into four groups of five animals each; groups 1 and 2 were control (positive and negative), while group 3 and 4 received vitamin C 500 mg/kg and silymarin 100 mg/kg respectively. Dosing was oral and daily for 6 days according to their body weights. All the animals except the positive control group (Group 1) were administered paracetamol 3 g/kg on the 7th day, and then observed for 24 hours before sample collection for biochemical indices and liver histological studies. Paracetamol caused a significant (p<0.05) increase in liver enzymes, significant (p<0.05) decrease in antioxidant enzymes, and necrosis in liver tissues when compared to the control. Administration of 500 mg/kg Vitamin C prior to induction of liver damage by PCM resulted in significant (p<0.05) decreased liver enzyme and well as an increase in the antioxidant enzymes. Pre-treatment of the animals with vitamin C showed a reversal of the toxic effect of paracetamol on the rats. Keywords: Vitamin C, liver enzymes, paracetamol, toxicity. https://www.Ajol.Info/index.php/jasem/article/view/188785Vitamin Cliver enzymesparacetamoltoxicity. |
| spellingShingle | E.G. Moke K.K. Anachuna P.O. Onyilo M. Emosivbe Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats Journal of Applied Sciences and Environmental Management Vitamin C liver enzymes paracetamol toxicity. |
| title | Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats |
| title_full | Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats |
| title_fullStr | Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats |
| title_full_unstemmed | Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats |
| title_short | Vitamin C <i>in-vivo</i> Effect on Liver Enzymes and Some Endogenous Antioxidants in Paracetamol-Induced Model of Liver Toxicity on Wistar Rats |
| title_sort | vitamin c i in vivo i effect on liver enzymes and some endogenous antioxidants in paracetamol induced model of liver toxicity on wistar rats |
| topic | Vitamin C liver enzymes paracetamol toxicity. |
| url | https://www.Ajol.Info/index.php/jasem/article/view/188785 |
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