Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database
Objective To evaluate the relationship between haemorrhoids and Graves’ disease (GD).Setting Using the nationwide data from Taiwan’s Longitudinal Health Insurance Database.Participants We conducted a retrospective study, stratified patients by International Classification of Diseases, Ninth Revision...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e053442.full |
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| author | Chia-Hung Kao Hsin-Hung Chen Shang-Rong Zhong Chun-Cheng Liao Chun-Hung Su Hei-Tung Yip |
| author_facet | Chia-Hung Kao Hsin-Hung Chen Shang-Rong Zhong Chun-Cheng Liao Chun-Hung Su Hei-Tung Yip |
| author_sort | Chia-Hung Kao |
| collection | DOAJ |
| description | Objective To evaluate the relationship between haemorrhoids and Graves’ disease (GD).Setting Using the nationwide data from Taiwan’s Longitudinal Health Insurance Database.Participants We conducted a retrospective study, stratified patients by International Classification of Diseases, Ninth Revision, Clinical Modification disease code and compared the incidence rate of GD between patients with and without haemorrhoids. The study period was from 2000 to 2010, with exclusion of patients with diagnosed haemorrhoids before 2000 or after 2009, and we analysed the HR of GD in the univariable and multivariable models as well as the cumulative incidence curves of GD by using Kaplan-Meier curves.Result This study included 13 165 and 52 660 patients with and without haemorrhoids, respectively. The mean follow-up duration was approximately 6 years. The incidence rate of GD was 1.57 and 1.13 per 1000 person-years in patients with and without haemorrhoids, respectively. The area under the cumulative incidence curve of GD in patients with haemorrhoids was higher than that of patients without haemorrhoids. The risk of GD increased by 1.39 times (95% CI 1.13 to 1.71) in patients with haemorrhoids compared with patients without haemorrhoids. In the subgroup analysis, women with haemorrhoids had a higher risk of GD (adjusted HR 1.44; 95% CI 1.13 to 1.83). Patients with haemorrhoids aged 30–39 years were more likely to develop GD (adjusted HR 1.73; 95% CI 1.18 to 2.55).Conclusion The findings of this study indicate that patients with haemorrhoids may have an increased risk of GD compared with other potential confounding factors. |
| format | Article |
| id | doaj-art-b703f0d27abe4aa4bcb93f48783d0d4e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-b703f0d27abe4aa4bcb93f48783d0d4e2024-12-11T00:15:09ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-053442Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance DatabaseChia-Hung Kao0Hsin-Hung Chen1Shang-Rong Zhong2Chun-Cheng Liao3Chun-Hung Su4Hei-Tung Yip5Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan1 Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Family Medicine, Taichung Armed Forces General Hospital, Taichung, TaiwanDepartment of Family Medicine, Taichung Armed Forces General Hospital, Taichung, TaiwanChung Shan Medical University, Taichung, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanObjective To evaluate the relationship between haemorrhoids and Graves’ disease (GD).Setting Using the nationwide data from Taiwan’s Longitudinal Health Insurance Database.Participants We conducted a retrospective study, stratified patients by International Classification of Diseases, Ninth Revision, Clinical Modification disease code and compared the incidence rate of GD between patients with and without haemorrhoids. The study period was from 2000 to 2010, with exclusion of patients with diagnosed haemorrhoids before 2000 or after 2009, and we analysed the HR of GD in the univariable and multivariable models as well as the cumulative incidence curves of GD by using Kaplan-Meier curves.Result This study included 13 165 and 52 660 patients with and without haemorrhoids, respectively. The mean follow-up duration was approximately 6 years. The incidence rate of GD was 1.57 and 1.13 per 1000 person-years in patients with and without haemorrhoids, respectively. The area under the cumulative incidence curve of GD in patients with haemorrhoids was higher than that of patients without haemorrhoids. The risk of GD increased by 1.39 times (95% CI 1.13 to 1.71) in patients with haemorrhoids compared with patients without haemorrhoids. In the subgroup analysis, women with haemorrhoids had a higher risk of GD (adjusted HR 1.44; 95% CI 1.13 to 1.83). Patients with haemorrhoids aged 30–39 years were more likely to develop GD (adjusted HR 1.73; 95% CI 1.18 to 2.55).Conclusion The findings of this study indicate that patients with haemorrhoids may have an increased risk of GD compared with other potential confounding factors.https://bmjopen.bmj.com/content/11/12/e053442.full |
| spellingShingle | Chia-Hung Kao Hsin-Hung Chen Shang-Rong Zhong Chun-Cheng Liao Chun-Hung Su Hei-Tung Yip Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database BMJ Open |
| title | Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database |
| title_full | Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database |
| title_fullStr | Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database |
| title_full_unstemmed | Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database |
| title_short | Association between haemorrhoids and Graves’ disease: a retrospective cohort study using data from Taiwan’s Longitudinal Health Insurance Database |
| title_sort | association between haemorrhoids and graves disease a retrospective cohort study using data from taiwan s longitudinal health insurance database |
| url | https://bmjopen.bmj.com/content/11/12/e053442.full |
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