Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis
Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/701760 |
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| author | Chikako Kiyohara Koichi Takayama Yoichi Nakanishi |
| author_facet | Chikako Kiyohara Koichi Takayama Yoichi Nakanishi |
| author_sort | Chikako Kiyohara |
| collection | DOAJ |
| description | Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR) =0.76, 95% confidence interval (CI) =0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls. |
| format | Article |
| id | doaj-art-b702ef98999649828b71a1629c67bdc9 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-b702ef98999649828b71a1629c67bdc92025-02-03T05:51:27ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/701760701760Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-AnalysisChikako Kiyohara0Koichi Takayama1Yoichi Nakanishi2Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanGenetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer. We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR) =0.76, 95% confidence interval (CI) =0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk. Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.http://dx.doi.org/10.4061/2010/701760 |
| spellingShingle | Chikako Kiyohara Koichi Takayama Yoichi Nakanishi Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis Journal of Nucleic Acids |
| title | Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis |
| title_full | Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis |
| title_fullStr | Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis |
| title_full_unstemmed | Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis |
| title_short | Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis |
| title_sort | lung cancer risk and genetic polymorphisms in dna repair pathways a meta analysis |
| url | http://dx.doi.org/10.4061/2010/701760 |
| work_keys_str_mv | AT chikakokiyohara lungcancerriskandgeneticpolymorphismsindnarepairpathwaysametaanalysis AT koichitakayama lungcancerriskandgeneticpolymorphismsindnarepairpathwaysametaanalysis AT yoichinakanishi lungcancerriskandgeneticpolymorphismsindnarepairpathwaysametaanalysis |