Accuracy and precision analyses of single-time-point dosimetry utilising physiologically-based pharmacokinetic modelling and non-linear mixed-effects modelling

Accuracy and precision analyses of single-time-point dosimetry utilising physiologically-based pharmacokinetic modelling and non-linear mixed-effects modelling

Abstract Purpose The aim of this study was to investigate the accuracy and precision of single-time-point (STP) dosimetry using a physiologically-based pharmacokinetic (PBPK) model with non-linear mixed-effects modelling (NLMEM). Methods Biokinetic data of [111In]In-DOTA-TATE in tumours, kidneys, li...

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Bibliographic Details
Main Authors: Indra Budiansah, Deni Hardiansyah, Ade Riana, Supriyanto Ardjo Pawiro, Ambros J. Beer, Gerhard Glatting
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:EJNMMI Physics
Subjects:
PBPK
NLMEM
STP
Accuracy
Precision
Online Access:https://doi.org/10.1186/s40658-025-00726-7
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