Association between microplastics and the functionalities of human gut microbiome
As an integral part of humans, the gut microbiome plays a significant role in the physiological and pathological processes of the host, and dysbiosis of the gut microbiome is linked to various diseases. The impact of microplastics on the diversity and composition of human gut microbiome has been rep...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015732 |
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| author | Bei Gao Lixia Chen Lizhi Wu Shirui Zhang Sunan Zhao Zhe Mo Zhijian Chen Pengcheng Tu |
| author_facet | Bei Gao Lixia Chen Lizhi Wu Shirui Zhang Sunan Zhao Zhe Mo Zhijian Chen Pengcheng Tu |
| author_sort | Bei Gao |
| collection | DOAJ |
| description | As an integral part of humans, the gut microbiome plays a significant role in the physiological and pathological processes of the host, and dysbiosis of the gut microbiome is linked to various diseases. The impact of microplastics on the diversity and composition of human gut microbiome has been reported previously. However, effects of microplastics on the functionality of the gut microbiome in humans have not been well studied. In the present study, concentrations of microplastics in human blood were detected through pyrolysis-gas chromatography/mass spectrometry in 39 adults. Five types of microplastics were found in human blood, including polyvinyl chloride, polyethylene, polypropylene, polystyrene, and polyamide 66. Shotgun metagenomic sequencing was further employed to analyze the metagenomes of the human stool samples and fecal samples from mice exposed to microplastics. Associations were found between microplastics and microbial species, as well as microbial genes encoding invasion-related virulence factors, quorum sensing, autoinducer and transporter system, and microplastic biodegradation enzymes. The findings are of significance to improve the understanding of functional changes in the gut microbiome associated with microplastic exposure, as well as raising awareness regarding the health risks of microplastics in the human population. |
| format | Article |
| id | doaj-art-b6ec33f7c579447aa8cdfdc6a595b568 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-b6ec33f7c579447aa8cdfdc6a595b5682025-02-12T05:29:23ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117497Association between microplastics and the functionalities of human gut microbiomeBei Gao0Lixia Chen1Lizhi Wu2Shirui Zhang3Sunan Zhao4Zhe Mo5Zhijian Chen6Pengcheng Tu7School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, ChinaSchool of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, ChinaDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, ChinaChangwang School of Honors, Nanjing University of Information Science and Technology, Nanjing 210044, ChinaChangwang School of Honors, Nanjing University of Information Science and Technology, Nanjing 210044, ChinaDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, ChinaDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, ChinaDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China; Corresponding author.As an integral part of humans, the gut microbiome plays a significant role in the physiological and pathological processes of the host, and dysbiosis of the gut microbiome is linked to various diseases. The impact of microplastics on the diversity and composition of human gut microbiome has been reported previously. However, effects of microplastics on the functionality of the gut microbiome in humans have not been well studied. In the present study, concentrations of microplastics in human blood were detected through pyrolysis-gas chromatography/mass spectrometry in 39 adults. Five types of microplastics were found in human blood, including polyvinyl chloride, polyethylene, polypropylene, polystyrene, and polyamide 66. Shotgun metagenomic sequencing was further employed to analyze the metagenomes of the human stool samples and fecal samples from mice exposed to microplastics. Associations were found between microplastics and microbial species, as well as microbial genes encoding invasion-related virulence factors, quorum sensing, autoinducer and transporter system, and microplastic biodegradation enzymes. The findings are of significance to improve the understanding of functional changes in the gut microbiome associated with microplastic exposure, as well as raising awareness regarding the health risks of microplastics in the human population.http://www.sciencedirect.com/science/article/pii/S0147651324015732MicroplasticsGut microbiotaMetagenomeQuorum sensingMicroplastic biodegradation |
| spellingShingle | Bei Gao Lixia Chen Lizhi Wu Shirui Zhang Sunan Zhao Zhe Mo Zhijian Chen Pengcheng Tu Association between microplastics and the functionalities of human gut microbiome Ecotoxicology and Environmental Safety Microplastics Gut microbiota Metagenome Quorum sensing Microplastic biodegradation |
| title | Association between microplastics and the functionalities of human gut microbiome |
| title_full | Association between microplastics and the functionalities of human gut microbiome |
| title_fullStr | Association between microplastics and the functionalities of human gut microbiome |
| title_full_unstemmed | Association between microplastics and the functionalities of human gut microbiome |
| title_short | Association between microplastics and the functionalities of human gut microbiome |
| title_sort | association between microplastics and the functionalities of human gut microbiome |
| topic | Microplastics Gut microbiota Metagenome Quorum sensing Microplastic biodegradation |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015732 |
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