Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model
Background: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological exam...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2025-04-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
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| Online Access: | https://ina-jghe.com/index.php/jghe/article/view/1052 |
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| author | Maria Bernadetta Nadya Blandina Vetinly . Tena Djuartina Riki Tenggara Iskandar R. Budianto |
| author_facet | Maria Bernadetta Nadya Blandina Vetinly . Tena Djuartina Riki Tenggara Iskandar R. Budianto |
| author_sort | Maria Bernadetta Nadya Blandina |
| collection | DOAJ |
| description | Background: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological examination. This study aims to determine the effect of red onion extract on the papillae elongation and neutrophil cells of the gastroesophageal junction in Sprague Dawley rats.
Methods: This experimental study was conducted on Sprague Dawley rats induced with 1 mL of HCl + 1 mL of ascorbic acid, administered into the gastric cardia of the rats, mixed with 1 mL of sodium thiocyanate (NaSCN) and 1.5 mL of sodium nitrite (NaNO₃) to develop a GERD model. The rats were then divided into ten groups with different treatments, including red onion extract (250, 500, 750 mg/kgBW) and PPI (pantoprazole).
Results: It was stated that there was a significant relationship between the effect of red onions and changes in papillae elongation in rats induced by GERD (P-value 0.05). The neutrophil cells showed no significance on the impact of red onion (p-value 0,05). Nor are the papillae elongation and the neutrophil cell changes dose-dependent.
Conclusion: A significant reduction in the histopathological appearance of papillae elongation was seen in the majority of the population. However, no significant results were found for the different doses of shallot extract.
Keywords: Gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells |
| format | Article |
| id | doaj-art-b6dfb6e86f9e4833a8a1265f01dbabf7 |
| institution | Kabale University |
| issn | 1411-4801 2302-8181 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj-art-b6dfb6e86f9e4833a8a1265f01dbabf72025-08-20T03:53:56ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812025-04-01261364210.24871/261202536-42915Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) ModelMaria Bernadetta Nadya Blandina0Vetinly .1Tena Djuartina2Riki Tenggara3Iskandar R. Budianto4Faculty of Medicine and Health Sciences of Atma Jaya University, Jakarta, IndonesiaDepartment of public health and nutrition sciences of Atma Jaya University, Jakarta, IndonesiaAnatomy department of Atma Jaya University, Jakarta, IndonesiaInternal medicine department of Atma Jaya University, Jakarta, IndonesiaSurgery department of Atma Jaya university, Jakarta, IndonesiaBackground: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological examination. This study aims to determine the effect of red onion extract on the papillae elongation and neutrophil cells of the gastroesophageal junction in Sprague Dawley rats. Methods: This experimental study was conducted on Sprague Dawley rats induced with 1 mL of HCl + 1 mL of ascorbic acid, administered into the gastric cardia of the rats, mixed with 1 mL of sodium thiocyanate (NaSCN) and 1.5 mL of sodium nitrite (NaNO₃) to develop a GERD model. The rats were then divided into ten groups with different treatments, including red onion extract (250, 500, 750 mg/kgBW) and PPI (pantoprazole). Results: It was stated that there was a significant relationship between the effect of red onions and changes in papillae elongation in rats induced by GERD (P-value 0.05). The neutrophil cells showed no significance on the impact of red onion (p-value 0,05). Nor are the papillae elongation and the neutrophil cell changes dose-dependent. Conclusion: A significant reduction in the histopathological appearance of papillae elongation was seen in the majority of the population. However, no significant results were found for the different doses of shallot extract. Keywords: Gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cellshttps://ina-jghe.com/index.php/jghe/article/view/1052gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells |
| spellingShingle | Maria Bernadetta Nadya Blandina Vetinly . Tena Djuartina Riki Tenggara Iskandar R. Budianto Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells |
| title | Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model |
| title_full | Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model |
| title_fullStr | Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model |
| title_full_unstemmed | Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model |
| title_short | Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model |
| title_sort | effectiveness of red onion extract allium cepa on the elongation of papillae and neutrophil cell in the gastroesophageal junction gej of sprague dawley strain rats gastroesophageal reflux disease gerd model |
| topic | gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells |
| url | https://ina-jghe.com/index.php/jghe/article/view/1052 |
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