Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice

Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice

Abstract This study aimed to improve the delivery efficacy of andrographolide (Andro) by encapsulating it in nanostructured lipid carriers (NLCs) and to evaluate its effectiveness in reducing systemic inflammation. These AndroNLCs exhibited homogeneity with a particle size of 131.40 ± 1.30 nm and ap...

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Bibliographic Details
Main Authors: Sarawut Lapmanee, Natchanon Rimsueb, Phichaporn Bunwatcharaphansakun, Katawut Namdee, Prapimpun Wongchitrat, Sakkarin Bhubhanil, Nattapon Supkamonseni, Natthawut Charoenphon, Anjaree Inchan, Rattaporn Saenmuangchin, Mattaka Khongkow
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Andrographolide
Inflammation
Nanostructured lipid carrier
Stress
TNF-alpha
Online Access:https://doi.org/10.1038/s41598-025-96758-1
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