Nature's weapons: Bioactive compounds as anti-cancer agents
Cancer represents a major global health burden, prompting continuous research for effective therapeutic strategies. Natural compounds derived from plants have emerged as potential strategies for preventing cancer and treatment because of their inherent pharmacological properties. This comprehensive...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-06-01
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| Series: | AIMS Public Health |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/publichealth.2024038?viewType=HTML |
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| author | Amogh Auti Madhura Tathode Maria Michela Marino Antonio Vitiello Andrea Ballini Francesco Miele Valeria Mazzone Alessia Ambrosino Mariarosaria Boccellino |
| author_facet | Amogh Auti Madhura Tathode Maria Michela Marino Antonio Vitiello Andrea Ballini Francesco Miele Valeria Mazzone Alessia Ambrosino Mariarosaria Boccellino |
| author_sort | Amogh Auti |
| collection | DOAJ |
| description | Cancer represents a major global health burden, prompting continuous research for effective therapeutic strategies. Natural compounds derived from plants have emerged as potential strategies for preventing cancer and treatment because of their inherent pharmacological properties. This comprehensive review aimed to evaluate the therapeutic potential of five key natural compounds: apigenin, quercetin, piperine, curcumin, and resveratrol in cancer prevention and therapy. By examining their molecular mechanisms and preclinical evidence, this review seeks to elucidate their role as potential adjuvants or stand-alone therapies in cancer management. The exploration of natural compounds as cancer therapeutics offers several advantages, including low toxicity, wide availability, and compatibility with conventional chemotherapeutic agents. We highlighted the current understanding of their anticancer mechanisms and clinical applications for advancing personalized cancer care to improve patient outcomes. We discussed the empirical findings from in vitro, in vivo, and clinical studies reporting biological activity and therapeutic efficacy in antioxidant, immunomodulatory, anti-carcinogenic, and chemo-sensitizing modes. Innovative delivery systems and personalized treatment approaches may further enhance their bioavailability and therapeutic utility in a synergistic approach with chemo- and radiotherapeutic disease management. This review underscores the importance of natural compounds in cancer prevention and treatment, promoting a multidisciplinary approach to the development of innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-b6dce3c7fb5843da88a9193aec59fe76 |
| institution | OA Journals |
| issn | 2327-8994 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Public Health |
| spelling | doaj-art-b6dce3c7fb5843da88a9193aec59fe762025-08-20T02:15:12ZengAIMS PressAIMS Public Health2327-89942024-06-0111374777210.3934/publichealth.2024038Nature's weapons: Bioactive compounds as anti-cancer agentsAmogh Auti0Madhura Tathode1Maria Michela Marino2Antonio Vitiello 3Andrea Ballini 4 Francesco Miele5Valeria Mazzone6Alessia Ambrosino 7Mariarosaria Boccellino81. Department of Precision Medicine, Università della Campania “Luigi Vanvitelli”, 80138 Naples, Italy1. Department of Precision Medicine, Università della Campania “Luigi Vanvitelli”, 80138 Naples, Italy1. Department of Precision Medicine, Università della Campania “Luigi Vanvitelli”, 80138 Naples, Italy2. Ministry of Health, Directorate-General for Health Prevention, 00144 Rome, Italy3. Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122, Foggia, Italy4. General Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, Italy5. Department of Experimental Medicine, Università della Campania “Luigi Vanvitelli”, 80138 Naples, Italy5. Department of Experimental Medicine, Università della Campania “Luigi Vanvitelli”, 80138 Naples, Italy1. Department of Precision Medicine, Università della Campania “Luigi Vanvitelli”, 80138 Naples, Italy6. Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, ItalyCancer represents a major global health burden, prompting continuous research for effective therapeutic strategies. Natural compounds derived from plants have emerged as potential strategies for preventing cancer and treatment because of their inherent pharmacological properties. This comprehensive review aimed to evaluate the therapeutic potential of five key natural compounds: apigenin, quercetin, piperine, curcumin, and resveratrol in cancer prevention and therapy. By examining their molecular mechanisms and preclinical evidence, this review seeks to elucidate their role as potential adjuvants or stand-alone therapies in cancer management. The exploration of natural compounds as cancer therapeutics offers several advantages, including low toxicity, wide availability, and compatibility with conventional chemotherapeutic agents. We highlighted the current understanding of their anticancer mechanisms and clinical applications for advancing personalized cancer care to improve patient outcomes. We discussed the empirical findings from in vitro, in vivo, and clinical studies reporting biological activity and therapeutic efficacy in antioxidant, immunomodulatory, anti-carcinogenic, and chemo-sensitizing modes. Innovative delivery systems and personalized treatment approaches may further enhance their bioavailability and therapeutic utility in a synergistic approach with chemo- and radiotherapeutic disease management. This review underscores the importance of natural compounds in cancer prevention and treatment, promoting a multidisciplinary approach to the development of innovative therapeutic strategies.https://www.aimspress.com/article/doi/10.3934/publichealth.2024038?viewType=HTMLphytochemicalschemopreventive agentsanti-inflammatory compoundsneuroprotective agentsantioxidant compounds |
| spellingShingle | Amogh Auti Madhura Tathode Maria Michela Marino Antonio Vitiello Andrea Ballini Francesco Miele Valeria Mazzone Alessia Ambrosino Mariarosaria Boccellino Nature's weapons: Bioactive compounds as anti-cancer agents AIMS Public Health phytochemicals chemopreventive agents anti-inflammatory compounds neuroprotective agents antioxidant compounds |
| title | Nature's weapons: Bioactive compounds as anti-cancer agents |
| title_full | Nature's weapons: Bioactive compounds as anti-cancer agents |
| title_fullStr | Nature's weapons: Bioactive compounds as anti-cancer agents |
| title_full_unstemmed | Nature's weapons: Bioactive compounds as anti-cancer agents |
| title_short | Nature's weapons: Bioactive compounds as anti-cancer agents |
| title_sort | nature s weapons bioactive compounds as anti cancer agents |
| topic | phytochemicals chemopreventive agents anti-inflammatory compounds neuroprotective agents antioxidant compounds |
| url | https://www.aimspress.com/article/doi/10.3934/publichealth.2024038?viewType=HTML |
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