Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol
The purpose of this study was to compare the efficacies of one initial intravitreal injection of aflibercept followed by a pro re nata (PRN; 1+PRN) regimen to those of three consecutive monthly injections followed by the PRN (3+PRN) regimen for diabetic macular edema (DME) with practical protocols....
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/1374891 |
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| author | Yuko Hayashi Tomoaki Tatsumi Toshiyuki Oshitari Tomomi Kaiho Yoko Takatsuna Miyuki Arai Takayuki Baba Shuichi Yamamoto |
| author_facet | Yuko Hayashi Tomoaki Tatsumi Toshiyuki Oshitari Tomomi Kaiho Yoko Takatsuna Miyuki Arai Takayuki Baba Shuichi Yamamoto |
| author_sort | Yuko Hayashi |
| collection | DOAJ |
| description | The purpose of this study was to compare the efficacies of one initial intravitreal injection of aflibercept followed by a pro re nata (PRN; 1+PRN) regimen to those of three consecutive monthly injections followed by the PRN (3+PRN) regimen for diabetic macular edema (DME) with practical protocols. The medical records of 95 eyes of 71 cases that were diagnosed with DME and had received intravitreal aflibercept (IVA) injections were reviewed. Fifty-seven eyes had received IVA with the 1+PRN regimen, and 38 eyes had received IVA with the 3+PRN regimen. The best-corrected visual acuity (BCVA) and the central macular thickness (CMT) were measured at the baseline and at 1, 3, 6, and 12 months after the IVA. The mean number of injections of the 1+PRN group was 2.9±1.7, which was significantly fewer than that of the 3+PRN group at 4.6±1.4 (P<0.001). The change of the mean BCVA before and after the IVA at 12 months of the 3+PRN group was −0.14±0.17 logMAR units which was significantly better than that of the 1+PRN group of −0.045±0.25 logMAR units (P=0.02). The change of the CMT before and after the IVA at 6 months of the 3+PRN group was −141.3±152.4 μm which was significantly more than that of the 1+PRN group at −86.1±117.8 μm (P=0.013). Although the mean number of injections was more than that in the 1+PRN regimen, the 3+PRN regimen had better visual outcomes at 12 months. In a practical protocol, we recommend the 3+PRN regimen for patients with DME (IRB#3541). |
| format | Article |
| id | doaj-art-b6d9d76c89be472392ff63d65c6c3eaa |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b6d9d76c89be472392ff63d65c6c3eaa2025-08-20T03:39:31ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/13748911374891Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical ProtocolYuko Hayashi0Tomoaki Tatsumi1Toshiyuki Oshitari2Tomomi Kaiho3Yoko Takatsuna4Miyuki Arai5Takayuki Baba6Shuichi Yamamoto7Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanThe purpose of this study was to compare the efficacies of one initial intravitreal injection of aflibercept followed by a pro re nata (PRN; 1+PRN) regimen to those of three consecutive monthly injections followed by the PRN (3+PRN) regimen for diabetic macular edema (DME) with practical protocols. The medical records of 95 eyes of 71 cases that were diagnosed with DME and had received intravitreal aflibercept (IVA) injections were reviewed. Fifty-seven eyes had received IVA with the 1+PRN regimen, and 38 eyes had received IVA with the 3+PRN regimen. The best-corrected visual acuity (BCVA) and the central macular thickness (CMT) were measured at the baseline and at 1, 3, 6, and 12 months after the IVA. The mean number of injections of the 1+PRN group was 2.9±1.7, which was significantly fewer than that of the 3+PRN group at 4.6±1.4 (P<0.001). The change of the mean BCVA before and after the IVA at 12 months of the 3+PRN group was −0.14±0.17 logMAR units which was significantly better than that of the 1+PRN group of −0.045±0.25 logMAR units (P=0.02). The change of the CMT before and after the IVA at 6 months of the 3+PRN group was −141.3±152.4 μm which was significantly more than that of the 1+PRN group at −86.1±117.8 μm (P=0.013). Although the mean number of injections was more than that in the 1+PRN regimen, the 3+PRN regimen had better visual outcomes at 12 months. In a practical protocol, we recommend the 3+PRN regimen for patients with DME (IRB#3541).http://dx.doi.org/10.1155/2021/1374891 |
| spellingShingle | Yuko Hayashi Tomoaki Tatsumi Toshiyuki Oshitari Tomomi Kaiho Yoko Takatsuna Miyuki Arai Takayuki Baba Shuichi Yamamoto Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol Journal of Diabetes Research |
| title | Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol |
| title_full | Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol |
| title_fullStr | Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol |
| title_full_unstemmed | Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol |
| title_short | Comparisons of One to Three Monthly Injections of Aflibercept for Diabetic Macular Edema by Practical Protocol |
| title_sort | comparisons of one to three monthly injections of aflibercept for diabetic macular edema by practical protocol |
| url | http://dx.doi.org/10.1155/2021/1374891 |
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