Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model

Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer’s mice model

Abstract Alzheimer’s disease (AD) is responsible for more than 80% of cases of dementia in senior individuals globally. In the current study, the role of modulation of the FGF1/PI3K/Akt pathway in the protective effect of tozasertib was evaluated. Experimental dementia was induced in mice by injecti...

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Main Authors: Darshpreet Kaur, Amarjot Kaur Grewal, Suad Hamdan Almasoudi, Ahmad H Almehmadi, Bshra A. Alsfouk, Amit Kumar, Varinder Singh, Athanasios Alexiou, Marios Papadakis, Nermeen N. Welson, Thakur Gurjeet Singh, Gaber El-Saber Batiha
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Tozasertib
Alzheimer’s disease
FGF1/PI3K/Akt pathway
Streptozotocin
Oxidative stress
Neuroinflammation
Online Access:https://doi.org/10.1038/s41598-025-13920-5
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