Influence of Ionization and the Addition of Cyclodextrins and Hydrophilic Excipients on the Solubility of Benzthiazide, Isoxicam, and Piroxicam

Influence of Ionization and the Addition of Cyclodextrins and Hydrophilic Excipients on the Solubility of Benzthiazide, Isoxicam, and Piroxicam

<b>Background</b>: The bioavailability of a drug depends, among other parameters, on solubility. One of the strategies used to enhance the solubility of sparingly soluble drugs is the use of excipients. Excipients can interact with the drug by increasing its solubility and/or stabilizing...

Full description

Saved in:

Bibliographic Details
Main Authors:	Diego Lucero-Borja, Rebeca Ruiz, Elisabet Fuguet, Clara Ràfols
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Pharmaceutics
Subjects:	solubility supersaturation shake-flask CheqSol excipients cyclodextrins
Online Access:	https://www.mdpi.com/1999-4923/17/5/571
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Screening and optimization of cyclodextrin glucanotransferase production by an alkaliphile Paenibacillus daejeonensis P-83
by: Dimple S. Pardhi, et al.
Published: (2025-06-01)

Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs
by: Milad Reda Qelliny, et al.
Published: (2025-05-01)

Host–Guest Complexation of Olmesartan Medoxomil by Heptakis(2,6-di-O-methyl)-β-cyclodextrin: Compatibility Study with Excipients
by: Dana Emilia Man, et al.
Published: (2024-12-01)

Formulation, in silico, in vitro characterization, cytotoxicity and cellular uptake of cyclodextrin complexes and ion pairing/salt formation with functional excipients (azelaic acid, tartaric acid, and arginine) with raloxifene
by: Hamdy Abdelkader, et al.
Published: (2025-06-01)

A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy
by: Andreas Schulte, et al.
Published: (2025-01-01)

Miniaturized shake-flask HPLC method for determination of distribution coefficient of drugs used in inflammatory bowel diseases
by: Brusač Edvin, et al.
Published: (2019-12-01)

EXCIPIENTS IN ORAL SUSPENSIONS
by: V. V. Vernikovsky, et al.
Published: (2019-01-01)

A review on the role of co-processed excipients in tablet formulations
by: Ankita S. Burande, et al.
Published: (2024-12-01)

Investigation of the solubility of protoporphyrin IX in aqueous and hydroalcoholic solvent systems
by: Michelly de Sá Matsuoka, et al.
Published: (2025-07-01)

Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude
by: Anne Neuss, et al.
Published: (2025-01-01)

THE IMPORTANCE OF CHROMATOGRAPHICALLY PURIFIED EXCIPIENTS
by: G. J. Rizzo, et al.
Published: (2019-01-01)

Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches
by: Chunting Zhang, et al.
Published: (2023-12-01)

Entecavir: stability and drug-excipient compatibility
by: Ariadne Botto Fiorot, et al.
Published: (2025-01-01)

TOXICOLOGICAL AND PHARMACOLOGICAL CHARACTERISTICS OF EXCIPIENTS OF DRUG PRODUCTS OF TORASEMIDE
by: D. Yu. Ivkin, et al.
Published: (2019-01-01)

The Use of Plant-Derived Biomaterials as Drug Formulation Excipients: An Application of Biomimetics in Dosage Form Development
by: Omobolanle Ayoyinka Omoteso, et al.
Published: (2024-05-01)

Defining Structure‐Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra‐Stable Biopharmaceuticals
by: Alexander N. Prossnitz, et al.
Published: (2025-02-01)

Reusable thiophene-based fluorescent sensor for detection of toxic Au³ ⁺ in real samples: Integrated spectroscopic and computational insight
by: Hasher Irshad, et al.
Published: (2025-11-01)

Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets
by: N. А. Symonenko, et al.
Published: (2023-11-01)

Synergic Effect of Methyl-β-Cyclodextrin and Hydrophilic Polymers on Nepafenac Solubilization: Development of a 0.3% Ophthalmic Solution
by: Maria Grazia Saita, et al.
Published: (2025-07-01)

Influence de l’hydroxypropyl-β-Cyclodextrine et de l’hydroxypropyl-γ-Cyclodextrine sur la solubilité aqueuse de l’acide ellagique
by: Isaie Nyamba, et al.
Published: (2024-12-01)

Investigation of the effect of the excipients quantitative characteristics on the main indicators of ophthalmic/otologic suspension quality
by: I. V. Zavalko
Published: (2013-04-01)

Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications
by: Svetlana A. Titova, et al.
Published: (2025-03-01)

The choice of auxiliary substances to obtain sublingual glycin tablets with thiotriazoline with direct compaction method Reporting 1. Study of the influence of excipients on the bulk density, the bulk density after shrinkage, the fluidity and the angle o
by: L. I. Kucherenko, et al.
Published: (2020-05-01)

Multifunctional investigation of “drug–excipient unification” of natural polysaccharide nanocarriers: A new paradigm from drug delivery to adjuvant therapy
by: Huan Yang, et al.
Published: (2025-09-01)

Investigation of excipients’ nature influence on the quality indices of effervescent tablets of acetylsalicylic acid, paracetamol and ascorbic acid
by: О. V. Tryhubchak, et al.
Published: (2018-03-01)

Development of Chitosan-Maize Starch based Co-processed excipient: As release retardant material
by: Smit Patel, et al.
Published: (2024-12-01)

Formulation and Characterization of Bilastine – Ternary Cyclodextrin Inclusion Complex
by: Eman B. H. Al-Khedairy, et al.
Published: (2025-03-01)

Recent progress in supersaturation-based SNEDDS: Formulation, mechanism, and biopharmaceutical performance
by: Sani Ega Priani, et al.
Published: (2025-09-01)

GELS FOR ORAL ADMINISTRATION. PART 2. EXCIPIENTS (REVIEW)
by: E. Y. Zagorulko, et al.
Published: (2019-01-01)

Comparison of lipophilic and size-exclusion membranes: the effect of stirring and cyclodextrin in the donor compartment
by: Petra Tozser, et al.
Published: (2025-07-01)

Assessment of mandatory declaration excipients in pediatric off label prescriptions in Spain
by: Irene Lizano-Díez, et al.
Published: (2025-07-01)

Study of the technological properties of excipients in the development of the composition of orally dispersible tablets
by: I. D. Kasymov, et al.
Published: (2021-12-01)

APPROACHES TO THE SELECTION OF EXCIPIENTS FOR DENTAL GEL WITH CETYLPYRIDINIUM CHLORIDE
by: E. Yu. Zagorulko, et al.
Published: (2021-06-01)

Cyclodextrins’ Internal Cavity Hydration: Insights from Theory and Experiment
by: Silvia Angelova, et al.
Published: (2025-01-01)

Role and Safety of Excipients in Syrups (Review)
by: V. V. Kosenko, et al.
Published: (2025-05-01)

Pengaruh Variasi Disintegran Avicel PH-102 dan Primogel terhadap Karakteristik Co-Processed Excipient
by: Hilya Nur Imtihani, et al.
Published: (2023-03-01)

Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach
by: Cristina Solomon, et al.
Published: (2025-05-01)

Study of the Influence of Pharmaceutical Excipients on the Solubility and Permeability of BCS Class II Drugs
by: Vivien Bárdos, et al.
Published: (2025-04-01)

The potentially harmful excipients in prescribed medications in a Neonatal Intensive Care Unit in Kosovo and available safer alternatives
by: Blerina Koshi, et al.
Published: (2022-02-01)

CYCLODEXTRINS AND THEIR APPLICATION IN PHARMACEUTICAL INDUSTRY (REVIEW)
by: S. A. Kedik, et al.
Published: (2019-01-01)