A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer
Abstract Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains a significant challenge. Here we introduce a hollow-tube-like hydrospongel (HTHSG) as an advanced neoadjuvant therapy. Constructed from cellulose nanofibers crosslinked with Fe3O4@PDA (polydopamine) nanopar...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62880-x |
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| author | Tao Wu Tenghui Li Chengzhi Zhang Yu Tian Hao Li Yuxin He Xu Yan Tianxing Gong Junhua Zhao Zhenning Wang |
| author_facet | Tao Wu Tenghui Li Chengzhi Zhang Yu Tian Hao Li Yuxin He Xu Yan Tianxing Gong Junhua Zhao Zhenning Wang |
| author_sort | Tao Wu |
| collection | DOAJ |
| description | Abstract Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains a significant challenge. Here we introduce a hollow-tube-like hydrospongel (HTHSG) as an advanced neoadjuvant therapy. Constructed from cellulose nanofibers crosslinked with Fe3O4@PDA (polydopamine) nanoparticles, the HTHSG combines quick swelling (~10 seconds) with high fracture strength (>250 kPa) for enhanced mechanical stability. The hydrospongel enables precise, localized delivery of the chemotherapeutic agent 5-FU directly to the tumor site. Beyond conventional chemotherapy, HTHSG employs electromagnetic induction to achieve targeted thermal ablation and chemodynamic therapy, minimizing collateral damage to healthy tissues. Comparative studies in orthotopic, cell-derived, and patient-derived xenograft models demonstrate the superior tumor-reduction efficacy of HTHSG over traditional neoadjuvant therapies. Feasibility studies in a beagle model and human-sized dummy model further validate the HTHSG’s potential for clinical application, showing preserved anal function and biocompatibility. These findings establish HTHSG as a promising pre-surgical treatment option for advanced-stage CRC, offering improved therapeutic outcomes and quality of life for patients. |
| format | Article |
| id | doaj-art-b6d12b2cb1a04571a0aadc048dad64cd |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b6d12b2cb1a04571a0aadc048dad64cd2025-08-20T04:02:54ZengNature PortfolioNature Communications2041-17232025-08-0116111910.1038/s41467-025-62880-xA hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancerTao Wu0Tenghui Li1Chengzhi Zhang2Yu Tian3Hao Li4Yuxin He5Xu Yan6Tianxing Gong7Junhua Zhao8Zhenning Wang9Department of Biomedical Engineering, Shenyang University of TechnologyDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Biomedical Engineering, Shenyang University of TechnologyDepartment of Biomedical Engineering, Shenyang University of TechnologyDepartment of Critical Care Medicine, The First Hospital of China Medical UniversityThe VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral DiseasesDepartment of Biomedical Engineering, Shenyang University of TechnologyDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityAbstract Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains a significant challenge. Here we introduce a hollow-tube-like hydrospongel (HTHSG) as an advanced neoadjuvant therapy. Constructed from cellulose nanofibers crosslinked with Fe3O4@PDA (polydopamine) nanoparticles, the HTHSG combines quick swelling (~10 seconds) with high fracture strength (>250 kPa) for enhanced mechanical stability. The hydrospongel enables precise, localized delivery of the chemotherapeutic agent 5-FU directly to the tumor site. Beyond conventional chemotherapy, HTHSG employs electromagnetic induction to achieve targeted thermal ablation and chemodynamic therapy, minimizing collateral damage to healthy tissues. Comparative studies in orthotopic, cell-derived, and patient-derived xenograft models demonstrate the superior tumor-reduction efficacy of HTHSG over traditional neoadjuvant therapies. Feasibility studies in a beagle model and human-sized dummy model further validate the HTHSG’s potential for clinical application, showing preserved anal function and biocompatibility. These findings establish HTHSG as a promising pre-surgical treatment option for advanced-stage CRC, offering improved therapeutic outcomes and quality of life for patients.https://doi.org/10.1038/s41467-025-62880-x |
| spellingShingle | Tao Wu Tenghui Li Chengzhi Zhang Yu Tian Hao Li Yuxin He Xu Yan Tianxing Gong Junhua Zhao Zhenning Wang A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer Nature Communications |
| title | A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer |
| title_full | A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer |
| title_fullStr | A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer |
| title_full_unstemmed | A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer |
| title_short | A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer |
| title_sort | hollow tube like hydrospongel for multimodal therapy of advanced colorectal cancer |
| url | https://doi.org/10.1038/s41467-025-62880-x |
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