Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis

The tumor-to-tumor metastasis phenomenon remains fairly uncommon, with fewer than 100 cases described to present time. Virtually any tumor can be a donor or a recipient neoplasm. Nevertheless, renal carcinomas have been implicated as the most common malignant tumors to harbor metastasis, while lung...

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Main Authors: Áurea Lima, Isa Peixoto, Susana Sarandão, Daniel Melo, Ângelo Rodrigues, Helena Pereira
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2021/3054232
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author Áurea Lima
Isa Peixoto
Susana Sarandão
Daniel Melo
Ângelo Rodrigues
Helena Pereira
author_facet Áurea Lima
Isa Peixoto
Susana Sarandão
Daniel Melo
Ângelo Rodrigues
Helena Pereira
author_sort Áurea Lima
collection DOAJ
description The tumor-to-tumor metastasis phenomenon remains fairly uncommon, with fewer than 100 cases described to present time. Virtually any tumor can be a donor or a recipient neoplasm. Nevertheless, renal carcinomas have been implicated as the most common malignant tumors to harbor metastasis, while lung and breast tumors are the most frequent donors. This article reports an extremely rare case of a breast cancer metastasis in a lung metastasis of clear cell type renal cell carcinoma that met all Campbell and coworkers’ tumor-to-tumor metastasis criteria. Additionally, we present the literature case reports of breast cancer metastasis in renal cell carcinomas and try to discuss the mechanisms underlying its occurrence. Since this phenomenon identification will impact the therapeutic strategy and it is not easily detected by image, the anatomopathological study of any and all suspicious lesions is of crucial importance. To the best of our knowledge, this is the first report of a metastasis inside a metastasis.
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issn 2090-6706
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publishDate 2021-01-01
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series Case Reports in Oncological Medicine
spelling doaj-art-b6cd923aae89438fb4b6997c827f10972025-08-20T02:23:11ZengWileyCase Reports in Oncological Medicine2090-67062090-67142021-01-01202110.1155/2021/30542323054232Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor MetastasisÁurea Lima0Isa Peixoto1Susana Sarandão2Daniel Melo3Ângelo Rodrigues4Helena Pereira5Medical Oncology Service, Centro Hospitalar de Entre o Douro e Vouga, EPE, Unit of Santa Maria da Feira, R. Dr. Cândido Pinho 5, 4520-211 Santa Maria da Feira, PortugalMedical Oncology Service, Centro Hospitalar Universitário do Porto, EPE, Largo Prof. Abel Salazar 4099-001 Porto, PortugalExternal Radiotherapy Service, Portuguese Institute of Oncology of Porto Francisco Gentil, EPE, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalPathologic Anatomy Service, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro 4200-319 Porto, PortugalPathologic Anatomy Service, Portuguese Institute of Oncology of Porto Francisco Gentil, EPE, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalExternal Radiotherapy Service, Portuguese Institute of Oncology of Porto Francisco Gentil, EPE, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalThe tumor-to-tumor metastasis phenomenon remains fairly uncommon, with fewer than 100 cases described to present time. Virtually any tumor can be a donor or a recipient neoplasm. Nevertheless, renal carcinomas have been implicated as the most common malignant tumors to harbor metastasis, while lung and breast tumors are the most frequent donors. This article reports an extremely rare case of a breast cancer metastasis in a lung metastasis of clear cell type renal cell carcinoma that met all Campbell and coworkers’ tumor-to-tumor metastasis criteria. Additionally, we present the literature case reports of breast cancer metastasis in renal cell carcinomas and try to discuss the mechanisms underlying its occurrence. Since this phenomenon identification will impact the therapeutic strategy and it is not easily detected by image, the anatomopathological study of any and all suspicious lesions is of crucial importance. To the best of our knowledge, this is the first report of a metastasis inside a metastasis.http://dx.doi.org/10.1155/2021/3054232
spellingShingle Áurea Lima
Isa Peixoto
Susana Sarandão
Daniel Melo
Ângelo Rodrigues
Helena Pereira
Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis
Case Reports in Oncological Medicine
title Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis
title_full Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis
title_fullStr Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis
title_full_unstemmed Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis
title_short Breast Cancer Metastasis in a Renal Carcinoma Pulmonary Metastasis: A Rare Example of Tumor-to-Tumor Metastasis
title_sort breast cancer metastasis in a renal carcinoma pulmonary metastasis a rare example of tumor to tumor metastasis
url http://dx.doi.org/10.1155/2021/3054232
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