A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty
The authors illustrate the merits of identifying the components of diseases (eg, bronchitis and airway hyper-responsiveness) that contribute to exacerbations in the management of a patient with severe asthma. Quantitative cell counts in sputum identified a neutrophilic – as opposed to eosinophilic –...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/459187 |
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| _version_ | 1832563047733919744 |
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| author | Conor Cox Melanie Kjarsgaard Michael G Surette P Gerard Cox Parameswaran Nair |
| author_facet | Conor Cox Melanie Kjarsgaard Michael G Surette P Gerard Cox Parameswaran Nair |
| author_sort | Conor Cox |
| collection | DOAJ |
| description | The authors illustrate the merits of identifying the components of diseases (eg, bronchitis and airway hyper-responsiveness) that contribute to exacerbations in the management of a patient with severe asthma. Quantitative cell counts in sputum identified a neutrophilic – as opposed to eosinophilic – bronchitis that enabled a stepwise weaning of prednisone. Molecular microbiology and extended culture methods identified anaerobes and other airway microbiome that helped to guide the use of antibiotics. Further control of asthma was achieved by performing bronchial thermoplasty. |
| format | Article |
| id | doaj-art-b6cd04a919b949b5af683bf3bae3d5c8 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-b6cd04a919b949b5af683bf3bae3d5c82025-02-03T01:21:07ZengWileyCanadian Respiratory Journal1198-22412015-01-0122422122410.1155/2015/459187A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial ThermoplastyConor Cox0Melanie Kjarsgaard1Michael G Surette2P Gerard Cox3Parameswaran Nair4Division of Respirology, Department of Medicine, St Joseph’s Healthcare and McMaster University, CanadaDivision of Respirology, Department of Medicine, St Joseph’s Healthcare and McMaster University, CanadaFarncombe Family Digestive Health Research Institute, Department of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, CanadaDivision of Respirology, Department of Medicine, St Joseph’s Healthcare and McMaster University, CanadaDivision of Respirology, Department of Medicine, St Joseph’s Healthcare and McMaster University, CanadaThe authors illustrate the merits of identifying the components of diseases (eg, bronchitis and airway hyper-responsiveness) that contribute to exacerbations in the management of a patient with severe asthma. Quantitative cell counts in sputum identified a neutrophilic – as opposed to eosinophilic – bronchitis that enabled a stepwise weaning of prednisone. Molecular microbiology and extended culture methods identified anaerobes and other airway microbiome that helped to guide the use of antibiotics. Further control of asthma was achieved by performing bronchial thermoplasty.http://dx.doi.org/10.1155/2015/459187 |
| spellingShingle | Conor Cox Melanie Kjarsgaard Michael G Surette P Gerard Cox Parameswaran Nair A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty Canadian Respiratory Journal |
| title | A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty |
| title_full | A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty |
| title_fullStr | A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty |
| title_full_unstemmed | A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty |
| title_short | A Multidimensional Approach to the Management of Severe Asthma: Inflammometry, Molecular Microbiology and Bronchial Thermoplasty |
| title_sort | multidimensional approach to the management of severe asthma inflammometry molecular microbiology and bronchial thermoplasty |
| url | http://dx.doi.org/10.1155/2015/459187 |
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