Clinical pathogenesis of typhoid fever
Human infections with Salmonella enterica results in two major groups of diseases: gastroenteritis and typhoid fever. Clinical observations suggest that gastroenteritis, caused by non-typhoidal Salmonella serovars, is characterized by a massive neutrophil influx, which keeps the infection localized...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2008-08-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/219 |
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| author | Manuela Raffatellu R. Paul Wilson Sebastian E. Winter Andreas J. Baumler |
| author_facet | Manuela Raffatellu R. Paul Wilson Sebastian E. Winter Andreas J. Baumler |
| author_sort | Manuela Raffatellu |
| collection | DOAJ |
| description | Human infections with Salmonella enterica results in two major groups of diseases: gastroenteritis and typhoid fever. Clinical observations suggest that gastroenteritis, caused by non-typhoidal Salmonella serovars, is characterized by a massive neutrophil influx, which keeps the infection localized to the intestinal mucosa. In contrast, the absence of neutrophilic intestinal infiltrates in the acute phase of typhoid fever suggests a propensity for typhoidal Salmonella serovars (S. Typhi, S. Paratyphi A, S. Paratyphi B and S. Paratyphi C) to evade aspects of the innate immune response and cause a systemic infection. The fact that there are no virulence genes shared by typhoidal Salmonella serovars that are absent from non-typhoidal Salmonella serovars, suggests that this innate immune evasion is mediated by different mechanisms in different typhoidal serovars. This review discusses what is known about the clinical pathogenesis of typhoid fever. |
| format | Article |
| id | doaj-art-b6cbc2ac0ea54635a224a03d1cdfbe24 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2008-08-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-b6cbc2ac0ea54635a224a03d1cdfbe242025-08-20T02:27:19ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802008-08-0120410.3855/jidc.219Clinical pathogenesis of typhoid feverManuela Raffatellu0R. Paul Wilson1Sebastian E. Winter2Andreas J. Baumler3Department of Medical Microbiology and Immunology, School of Medicine, University of California at DavisDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at DavisDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at DavisDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at DavisHuman infections with Salmonella enterica results in two major groups of diseases: gastroenteritis and typhoid fever. Clinical observations suggest that gastroenteritis, caused by non-typhoidal Salmonella serovars, is characterized by a massive neutrophil influx, which keeps the infection localized to the intestinal mucosa. In contrast, the absence of neutrophilic intestinal infiltrates in the acute phase of typhoid fever suggests a propensity for typhoidal Salmonella serovars (S. Typhi, S. Paratyphi A, S. Paratyphi B and S. Paratyphi C) to evade aspects of the innate immune response and cause a systemic infection. The fact that there are no virulence genes shared by typhoidal Salmonella serovars that are absent from non-typhoidal Salmonella serovars, suggests that this innate immune evasion is mediated by different mechanisms in different typhoidal serovars. This review discusses what is known about the clinical pathogenesis of typhoid fever.https://jidc.org/index.php/journal/article/view/219SalmonellaTyphipathogenesis |
| spellingShingle | Manuela Raffatellu R. Paul Wilson Sebastian E. Winter Andreas J. Baumler Clinical pathogenesis of typhoid fever Journal of Infection in Developing Countries Salmonella Typhi pathogenesis |
| title | Clinical pathogenesis of typhoid fever |
| title_full | Clinical pathogenesis of typhoid fever |
| title_fullStr | Clinical pathogenesis of typhoid fever |
| title_full_unstemmed | Clinical pathogenesis of typhoid fever |
| title_short | Clinical pathogenesis of typhoid fever |
| title_sort | clinical pathogenesis of typhoid fever |
| topic | Salmonella Typhi pathogenesis |
| url | https://jidc.org/index.php/journal/article/view/219 |
| work_keys_str_mv | AT manuelaraffatellu clinicalpathogenesisoftyphoidfever AT rpaulwilson clinicalpathogenesisoftyphoidfever AT sebastianewinter clinicalpathogenesisoftyphoidfever AT andreasjbaumler clinicalpathogenesisoftyphoidfever |