Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants
Objective This study aimed to examine rheumatoid arthritis (RA) risk associated with hormonal and reproductive factors in women from the large cohort of the UK Biobank.Methods Data on hormonal and reproductive factors in women were collected from a prospective cohort of 223 526 UK Biobank participan...
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BMJ Publishing Group
2024-02-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/10/1/e003338.full |
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| author | Tian Tian Peng Wang Jing Ni Chan-Na Zhao Hai-Feng Pan Tian He Yang Fang Yi-Sheng He Ling-Qiong Jiang Ruo-Di Zhang Harry Asena Musonye Hao-Yun Zhao Zhao-Xing Gao |
| author_facet | Tian Tian Peng Wang Jing Ni Chan-Na Zhao Hai-Feng Pan Tian He Yang Fang Yi-Sheng He Ling-Qiong Jiang Ruo-Di Zhang Harry Asena Musonye Hao-Yun Zhao Zhao-Xing Gao |
| author_sort | Tian Tian |
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| description | Objective This study aimed to examine rheumatoid arthritis (RA) risk associated with hormonal and reproductive factors in women from the large cohort of the UK Biobank.Methods Data on hormonal and reproductive factors in women were collected from a prospective cohort of 223 526 UK Biobank participants. The potential relationship between reproductive factors and RA risk was assessed using restricted cubic spline. Hazard ratios (HR) were estimated using Cox proportional hazard regressions.Results During a median follow-up of 12.39 years, 3313 women with RA were identified. Age at menarche >14 years was associated with a greater RA risk (HR 1.13, 95% CI 1.02 to 1.26) compared with menarche at 13. The multiple adjusted HR for RA in women with menopause at <45 years was 1.46. Reproductive years <33 increased the risk of RA (HR 1.39, 95% CI 1.21 to 1.59). Compared with those with 2 children, women with ≥4 children were associated with a higher risk of RA (HR 1.18, 95% CI 1.04 to 1.34). Women who had a hysterectomy (HR 1.40, 95% CI 1.25 to 1.56) or oophorectomy (HR 1.21, 95% CI 1.08 to 1.35) had a higher risk of RA than those without a hysterectomy or oophorectomy. Both hormone replacement therapy (HRT) use (HR 1.46, 95% CI 1.35 to 1.57) and HRT duration (HR 1.02, 95% CI 1.01 to 1.03) were associated with a higher risk of RA.Conclusions Some hormonal and reproductive factors were associated with a higher risk of RA. Hormonal and reproductive factors should be considered in risk assessment and formulating management plans in female patients with RA. |
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| id | doaj-art-b6c856201a3e4e96ba3d598d7135a69b |
| institution | OA Journals |
| issn | 2056-5933 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
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| series | RMD Open |
| spelling | doaj-art-b6c856201a3e4e96ba3d598d7135a69b2025-08-20T01:48:48ZengBMJ Publishing GroupRMD Open2056-59332024-02-0110110.1136/rmdopen-2023-003338Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participantsTian Tian0Peng Wang1Jing Ni2Chan-Na Zhao3Hai-Feng Pan4Tian He5Yang Fang6Yi-Sheng He7Ling-Qiong Jiang8Ruo-Di Zhang9Harry Asena Musonye10Hao-Yun Zhao11Zhao-Xing Gao122 National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China3 Department of Pharmacology, Medical School of Huanghe Science and Technology University, Zhengzhou, Henan, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Kidney Disease, Inflammation & Immunity Mediated Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaDepartment of Clinical Medicine, Anhui Medical University, Hefei, ChinaDepartment of Epidemiology and Biostatistics, Anhui Medical University School of Public Health, Hefei, Anhui, ChinaObjective This study aimed to examine rheumatoid arthritis (RA) risk associated with hormonal and reproductive factors in women from the large cohort of the UK Biobank.Methods Data on hormonal and reproductive factors in women were collected from a prospective cohort of 223 526 UK Biobank participants. The potential relationship between reproductive factors and RA risk was assessed using restricted cubic spline. Hazard ratios (HR) were estimated using Cox proportional hazard regressions.Results During a median follow-up of 12.39 years, 3313 women with RA were identified. Age at menarche >14 years was associated with a greater RA risk (HR 1.13, 95% CI 1.02 to 1.26) compared with menarche at 13. The multiple adjusted HR for RA in women with menopause at <45 years was 1.46. Reproductive years <33 increased the risk of RA (HR 1.39, 95% CI 1.21 to 1.59). Compared with those with 2 children, women with ≥4 children were associated with a higher risk of RA (HR 1.18, 95% CI 1.04 to 1.34). Women who had a hysterectomy (HR 1.40, 95% CI 1.25 to 1.56) or oophorectomy (HR 1.21, 95% CI 1.08 to 1.35) had a higher risk of RA than those without a hysterectomy or oophorectomy. Both hormone replacement therapy (HRT) use (HR 1.46, 95% CI 1.35 to 1.57) and HRT duration (HR 1.02, 95% CI 1.01 to 1.03) were associated with a higher risk of RA.Conclusions Some hormonal and reproductive factors were associated with a higher risk of RA. Hormonal and reproductive factors should be considered in risk assessment and formulating management plans in female patients with RA.https://rmdopen.bmj.com/content/10/1/e003338.full |
| spellingShingle | Tian Tian Peng Wang Jing Ni Chan-Na Zhao Hai-Feng Pan Tian He Yang Fang Yi-Sheng He Ling-Qiong Jiang Ruo-Di Zhang Harry Asena Musonye Hao-Yun Zhao Zhao-Xing Gao Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants RMD Open |
| title | Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants |
| title_full | Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants |
| title_fullStr | Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants |
| title_full_unstemmed | Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants |
| title_short | Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants |
| title_sort | hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women a prospective cohort study with 223 526 participants |
| url | https://rmdopen.bmj.com/content/10/1/e003338.full |
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