Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells

Acridocarpus smeathmannii root extracts inhibit human prostate and bladder smooth muscle contraction, porcine arterial vasoconstriction, and cytotoxicity of prostate stromal cells

IntroductionThe limited tolerability and efficacy of synthetic drugs have hindered the effective management of lower urinary tract symptoms (LUTSs). In African traditional medicine, species of the genus Acridocarpus (Malpighiaceae) are commonly used to treat reproductive disorders. In this study, we...

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Bibliographic Details
Main Authors: Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G. Stief, Wolfgang Eisenreich, Martin Hennenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Acridocarpus smeathmannii root extract
lower urinary tract symptoms
porcine arteries
smooth muscle contraction
phytomedicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1621346/full
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