Novel distribution of the secretory leucocyte proteinase inhibitor in kidney
The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. T...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350120102389 |
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| _version_ | 1832567680002949120 |
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| author | Sophie Ohlsson Irena Ljungkrantz Kjell Ohlsson Mårten Segelmark Jörgen Wieslander |
| author_facet | Sophie Ohlsson Irena Ljungkrantz Kjell Ohlsson Mårten Segelmark Jörgen Wieslander |
| author_sort | Sophie Ohlsson |
| collection | DOAJ |
| description | The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells. |
| format | Article |
| id | doaj-art-b6c0826085704ceea9a6b5e4f03a396d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b6c0826085704ceea9a6b5e4f03a396d2025-02-03T01:00:49ZengWileyMediators of Inflammation0962-93511466-18612001-01-0110634735010.1080/09629350120102389Novel distribution of the secretory leucocyte proteinase inhibitor in kidneySophie Ohlsson0Irena Ljungkrantz1Kjell Ohlsson2Mårten Segelmark3Jörgen Wieslander4Department of Nephrology, Lund University Hospital, Lund SE-221 85, SwedenDepartment of Surgical Pathophysiology, Malmö University Hospital, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, Malmö University Hospital, Malmö SE-205 02, SwedenDepartment of Nephrology, Lund University Hospital, Lund SE-221 85, SwedenWieslab AB, Ideon, Lund SE-223 70, SwedenThe secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells.http://dx.doi.org/10.1080/09629350120102389 |
| spellingShingle | Sophie Ohlsson Irena Ljungkrantz Kjell Ohlsson Mårten Segelmark Jörgen Wieslander Novel distribution of the secretory leucocyte proteinase inhibitor in kidney Mediators of Inflammation |
| title | Novel distribution of the secretory leucocyte proteinase inhibitor in kidney |
| title_full | Novel distribution of the secretory leucocyte proteinase inhibitor in kidney |
| title_fullStr | Novel distribution of the secretory leucocyte proteinase inhibitor in kidney |
| title_full_unstemmed | Novel distribution of the secretory leucocyte proteinase inhibitor in kidney |
| title_short | Novel distribution of the secretory leucocyte proteinase inhibitor in kidney |
| title_sort | novel distribution of the secretory leucocyte proteinase inhibitor in kidney |
| url | http://dx.doi.org/10.1080/09629350120102389 |
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