Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture
The data оп cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The study of the antiviral activity of antivir...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/359 |
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| author | I. T. Fedyakina M. YU. Shchelkanov P. G. Deryabin I. A. Leneva N. V. Gudova T. V. Kondratyeva D. K. Lvov |
| author_facet | I. T. Fedyakina M. YU. Shchelkanov P. G. Deryabin I. A. Leneva N. V. Gudova T. V. Kondratyeva D. K. Lvov |
| author_sort | I. T. Fedyakina |
| collection | DOAJ |
| description | The data оп cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The study of the antiviral activity of antivirals in the MDCK cells culture demonstrated that Arbidol, Rimantadine and Ribavirin efficiently inhibited reproduction of the highly pathogenic H5N1 influenza viruses isolated from sick birds. Arbidol and Oseltamivir carboxylate selectively inhibited reproduction of the pandemic 2009 H1N1 influenza A viruses with changed specificity to the cell receptors, causing severe influenza in men, while remantadine had no effect on their reproduction. |
| format | Article |
| id | doaj-art-b6c00afa55564d71aca413c7a9d19fa7 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-b6c00afa55564d71aca413c7a9d19fa72025-08-20T03:42:02ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01563-439358Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell CultureI. T. Fedyakina0M. YU. Shchelkanov1P. G. Deryabin2I. A. Leneva3N. V. Gudova4T. V. Kondratyeva5D. K. Lvov6D.I. Ivanovsky Research Institute of Virology, MoscowD.I. Ivanovsky Research Institute of Virology, MoscowD.I. Ivanovsky Research Institute of Virology, MoscowCentre for Chemistry of Drugs, All-Russian Research Chemicopharmaceutical Institute, MoscowCentre for Chemistry of Drugs, All-Russian Research Chemicopharmaceutical Institute, MoscowJSC Pharmstandart, Moscow Region, DolgoprudnyiD.I. Ivanovsky Research Institute of Virology, MoscowThe data оп cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The study of the antiviral activity of antivirals in the MDCK cells culture demonstrated that Arbidol, Rimantadine and Ribavirin efficiently inhibited reproduction of the highly pathogenic H5N1 influenza viruses isolated from sick birds. Arbidol and Oseltamivir carboxylate selectively inhibited reproduction of the pandemic 2009 H1N1 influenza A viruses with changed specificity to the cell receptors, causing severe influenza in men, while remantadine had no effect on their reproduction.https://www.antibiotics-chemotherapy.ru/jour/article/view/359influenza virus arimantadineoseltamivirarbidolribavirin |
| spellingShingle | I. T. Fedyakina M. YU. Shchelkanov P. G. Deryabin I. A. Leneva N. V. Gudova T. V. Kondratyeva D. K. Lvov Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture Антибиотики и Химиотерапия influenza virus a rimantadine oseltamivir arbidol ribavirin |
| title | Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture |
| title_full | Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture |
| title_fullStr | Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture |
| title_full_unstemmed | Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture |
| title_short | Susceptibility of Pandemic Influenza Virus A 2009 H1N1 and Highly Pathogenic Avian Influenza Virus A H5N1 to Antiinfluenza Agents in Cell Culture |
| title_sort | susceptibility of pandemic influenza virus a 2009 h1n1 and highly pathogenic avian influenza virus a h5n1 to antiinfluenza agents in cell culture |
| topic | influenza virus a rimantadine oseltamivir arbidol ribavirin |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/359 |
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