Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen

Summary: Blood cancers are generally more common in males, and the prevalence of most mutations that drive clonal hematopoiesis and myeloid malignancies is higher in males. In contrast, hematopoietic DNMT3A mutations are more common in females. Among ∼450,000 participants in the UK Biobank, the prev...

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Bibliographic Details
Main Authors: Julia Stomper, Abhishek Niroula, Roger Belizaire, Marie McConkey, Tagore Sanketh Bandaru, Benjamin L. Ebert
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725002657
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