Inhibition of VEGF signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via Wnt/β-catenin pathway

Inhibition of VEGF signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via Wnt/β-catenin pathway

Abstract Background Current challenges in Chimeric Antigen Receptor (CAR) -T cell therapy for hematological cancers include T cell exhaustion and limited persistence, which contribute to cancer relapse. Methods The effects of Axitinib, a VEGFR inhibitor, on the biological functions of CAR-T cells in...

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Bibliographic Details
Main Authors: Suwan Wu, Yiyi Wei, Yingqi Qiu, Kexin Ai, Mu Chen, Hao Wang, Honghao Zhang, Qingyan Cen, Peiyun Liao, Xiangyang Ding, Xiaoling Xie, Yuhua Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Chimeric antigen receptor T cells
Acute lymphoblastic leukemia
Vascular endothelial growth factor receptor
Differentiation
Exhaustion
Online Access:https://doi.org/10.1186/s12967-024-05907-z
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