Seagrass Enhalus acoroides extract mitigates obesity and diabetes via GLP-1, PPARγ, SREBP-1c modulation and gut microbiome restoration in diabetic zebrafish

Seagrass Enhalus acoroides extract mitigates obesity and diabetes via GLP-1, PPARγ, SREBP-1c modulation and gut microbiome restoration in diabetic zebrafish

Abstract Background The global rise in obesity and type 2 diabetes highlights the need for safe and effective therapeutic interventions. Enhalus acoroides is a tropical seagrass rich in carotenoids and other bioactives. Its potential for metabolic regulation has been suggested in vitro, but in vivo...

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Main Authors: Marcello Mikhael Kadharusman, Rony Abdi Syahputra, Rudy Kurniawan, Edwin Hadinata, Raymond Rubianto Tjandrawinata, Nurpudji Astuti Taslim, Raffaele Romano, Antonello Santini, Fahrul Nurkolis
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Metabolic syndrome
Functional food
Seagrass
Gut microbiome
In vivo
Marine product
Online Access:https://doi.org/10.1186/s13098-025-01823-4
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