Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018)
ObjectiveThis study aims to sheds light on the correlation between urinary cadmium (Cd-U) exposure and coronary heart disease (CHD) and the mediating effects of serum alkaline phosphatase (ALP) based on a sample of adults in the United States.MethodsA comprehensive cross-sectional study was performe...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1415269/full |
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| author | Xuhui Ma Yang Yang Qingjun Jiang |
| author_facet | Xuhui Ma Yang Yang Qingjun Jiang |
| author_sort | Xuhui Ma |
| collection | DOAJ |
| description | ObjectiveThis study aims to sheds light on the correlation between urinary cadmium (Cd-U) exposure and coronary heart disease (CHD) and the mediating effects of serum alkaline phosphatase (ALP) based on a sample of adults in the United States.MethodsA comprehensive cross-sectional study was performed on 8,998 CHD participants who participated in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. Weighted logistic regression was employed to elucidate the association between Cd-U and the likelihood of CHD. We investigated the link of Cd-U exposure to the prevalence of CHD using limited cubic spline models to analyze the exposure-dose relationship. In addition, mediation analyses were conducted to explore the role of serum ALP in metal exposure-induced CHD.Results8,998 participants were included, and 323 among them were diagnosed with CHD. Our study found that elevated levels of Cd-U in U.S. are linked to a heightened likelihood of CHD. Additionally, there is a non-linear positive correlation between Cd-U and CHD, and a saturation effect was observed. Further mediation analysis revealed that the association between Cd-U and CHD prevalence was mediated through serum ALP mellitus, with the mediation percentage being 2.5% (P value <0.05).ConclusionsOur study indicates a strong association between the levels of Cd-U exposure in urine and the likelihood of CHD, with serum ALP serving as a mediator. |
| format | Article |
| id | doaj-art-b6b43b5650004e0e8fe2be90194377a4 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-b6b43b5650004e0e8fe2be90194377a42025-08-20T02:07:24ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-11-011110.3389/fcvm.2024.14152691415269Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018)Xuhui Ma0Yang Yang1Qingjun Jiang2Department of Cardiology, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Otolaryngology, Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, ChinaDepartment of Cardiovascular Medicine, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia Hui Autonomous Region, ChinaObjectiveThis study aims to sheds light on the correlation between urinary cadmium (Cd-U) exposure and coronary heart disease (CHD) and the mediating effects of serum alkaline phosphatase (ALP) based on a sample of adults in the United States.MethodsA comprehensive cross-sectional study was performed on 8,998 CHD participants who participated in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. Weighted logistic regression was employed to elucidate the association between Cd-U and the likelihood of CHD. We investigated the link of Cd-U exposure to the prevalence of CHD using limited cubic spline models to analyze the exposure-dose relationship. In addition, mediation analyses were conducted to explore the role of serum ALP in metal exposure-induced CHD.Results8,998 participants were included, and 323 among them were diagnosed with CHD. Our study found that elevated levels of Cd-U in U.S. are linked to a heightened likelihood of CHD. Additionally, there is a non-linear positive correlation between Cd-U and CHD, and a saturation effect was observed. Further mediation analysis revealed that the association between Cd-U and CHD prevalence was mediated through serum ALP mellitus, with the mediation percentage being 2.5% (P value <0.05).ConclusionsOur study indicates a strong association between the levels of Cd-U exposure in urine and the likelihood of CHD, with serum ALP serving as a mediator.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1415269/fullcoronary heart diseaseurinary cadmiummetalsNHANEScross-sectional study |
| spellingShingle | Xuhui Ma Yang Yang Qingjun Jiang Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018) Frontiers in Cardiovascular Medicine coronary heart disease urinary cadmium metals NHANES cross-sectional study |
| title | Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018) |
| title_full | Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018) |
| title_fullStr | Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018) |
| title_full_unstemmed | Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018) |
| title_short | Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009–2018) |
| title_sort | association between urinary cadmium levels and prevalence of coronary artery disease nhanes cross sectional study 2009 2018 |
| topic | coronary heart disease urinary cadmium metals NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1415269/full |
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