Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study
Abstract Background As the number of older people with HIV is expected to grow and experience age-related cognitive declines, concerns mount that such existing cognitive impairments may become exacerbated in already cognitively vulnerable subgroups such as women with HIV. These cognitive impairments...
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BMC
2025-08-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04249-7 |
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| author | David E. Vance Lang Lang Pauline M. Maki Danyang Yu Raha Dastgheyb Yuezhe Wang Gayle Springer Kathryn Anastos Deborah R. Gustafson Kathleen M. Weber Derek M. Dykxhoorn Joel Milam Monica M. Diaz Seble G. Kassaye Drenna Waldrop Yanxun Xu Leah. H. Rubin |
| author_facet | David E. Vance Lang Lang Pauline M. Maki Danyang Yu Raha Dastgheyb Yuezhe Wang Gayle Springer Kathryn Anastos Deborah R. Gustafson Kathleen M. Weber Derek M. Dykxhoorn Joel Milam Monica M. Diaz Seble G. Kassaye Drenna Waldrop Yanxun Xu Leah. H. Rubin |
| author_sort | David E. Vance |
| collection | DOAJ |
| description | Abstract Background As the number of older people with HIV is expected to grow and experience age-related cognitive declines, concerns mount that such existing cognitive impairments may become exacerbated in already cognitively vulnerable subgroups such as women with HIV. These cognitive impairments can develop into everyday functional impairment in either basic or instrumental activities of daily living. Methods In the Women’s Interagency HIV Study, we examined the association between objective cognitive test performance and the self-rated Lawton and Brody scale of Independent Activities of Daily Living (IADL) in 754 older (50+) women with HIV (WWH; 84% virally suppressed). To handle this longitudinal data, weighted logistic mixed effect models examined associations between cognitive domain performance (predictor) and functional outcomes (IADL item level scores). Results In the total sample, poorer motor performance was associated with impairments in home repairs, housekeeping, and laundry and poorer executive functioning was associated with impairment in planning social activities. Among older virally suppressed-WWH, poorer motor performance was associated with deficits in home repair and poorer executive performance was associated with deficits in planning social activities. Conclusion Since motor and executive performance were related to impairments in certain IADLs, strategies such as cognitive training targeting these domains could improve everyday functioning. Such approaches could improve autonomy as WWH age. |
| format | Article |
| id | doaj-art-b6b395e8470a4b67a8ac3f94fb6efdee |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-b6b395e8470a4b67a8ac3f94fb6efdee2025-08-20T03:42:51ZengBMCBMC Neurology1471-23772025-08-0125111210.1186/s12883-025-04249-7Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV studyDavid E. Vance0Lang Lang1Pauline M. Maki2Danyang Yu3Raha Dastgheyb4Yuezhe Wang5Gayle Springer6Kathryn Anastos7Deborah R. Gustafson8Kathleen M. Weber9Derek M. Dykxhoorn10Joel Milam11Monica M. Diaz12Seble G. Kassaye13Drenna Waldrop14Yanxun Xu15Leah. H. Rubin16School of Nursing, University of Alabama at BirminghamDepartment of Applied Mathematics and Statistics, Johns Hopkins UniversityDepartments of Psychiatry, Psychology and OB/GYN, University of Illinois ChicagoDepartment of Applied Mathematics and Statistics, Johns Hopkins UniversityDepartment of Neurology, Johns Hopkins University School of MedicineDepartment of Applied Mathematics and Statistics, Johns Hopkins UniversityDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Neurology, State University of New York Downstate Health Sciences UniversityHektoen Institute of MedicineDepartment of Human Genetics, Dr. John T. Macdonald Foundation, University of MiamiDepartment of Epidemiology and Biostatistics, University of CaliforniaDepartment of Neurology, University of North Carolina at Chapel HillDepartment of Medicine, Division of Infectious Diseases and Tropical Medicine, Georgetown UniversityNell Hodgson Woodruff School of Nursing, Emory UniversityDepartment of Applied Mathematics and Statistics, Johns Hopkins UniversityDepartment of Neurology, Johns Hopkins University School of MedicineAbstract Background As the number of older people with HIV is expected to grow and experience age-related cognitive declines, concerns mount that such existing cognitive impairments may become exacerbated in already cognitively vulnerable subgroups such as women with HIV. These cognitive impairments can develop into everyday functional impairment in either basic or instrumental activities of daily living. Methods In the Women’s Interagency HIV Study, we examined the association between objective cognitive test performance and the self-rated Lawton and Brody scale of Independent Activities of Daily Living (IADL) in 754 older (50+) women with HIV (WWH; 84% virally suppressed). To handle this longitudinal data, weighted logistic mixed effect models examined associations between cognitive domain performance (predictor) and functional outcomes (IADL item level scores). Results In the total sample, poorer motor performance was associated with impairments in home repairs, housekeeping, and laundry and poorer executive functioning was associated with impairment in planning social activities. Among older virally suppressed-WWH, poorer motor performance was associated with deficits in home repair and poorer executive performance was associated with deficits in planning social activities. Conclusion Since motor and executive performance were related to impairments in certain IADLs, strategies such as cognitive training targeting these domains could improve everyday functioning. Such approaches could improve autonomy as WWH age.https://doi.org/10.1186/s12883-025-04249-7HIVCognitionMotor functionInstrumental activities of daily livingActivities of daily living |
| spellingShingle | David E. Vance Lang Lang Pauline M. Maki Danyang Yu Raha Dastgheyb Yuezhe Wang Gayle Springer Kathryn Anastos Deborah R. Gustafson Kathleen M. Weber Derek M. Dykxhoorn Joel Milam Monica M. Diaz Seble G. Kassaye Drenna Waldrop Yanxun Xu Leah. H. Rubin Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study BMC Neurology HIV Cognition Motor function Instrumental activities of daily living Activities of daily living |
| title | Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study |
| title_full | Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study |
| title_fullStr | Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study |
| title_full_unstemmed | Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study |
| title_short | Cognitive predictors of everyday functioning in women with HIV: findings from the women’s interagency HIV study |
| title_sort | cognitive predictors of everyday functioning in women with hiv findings from the women s interagency hiv study |
| topic | HIV Cognition Motor function Instrumental activities of daily living Activities of daily living |
| url | https://doi.org/10.1186/s12883-025-04249-7 |
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