Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial
Porous tantalum (Ta) has exhibited exceptional biocompatibility and osseointegration capacity as an advanced orthopedic implant material. This study employs selective laser melting (SLM) to fabricate porous Ta scaffolds with controlled porosities (65 %, 75 %, 85 %, 90 %), systematically investigatin...
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Elsevier
2025-05-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785425013511 |
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| author | Junlei Li Liangliang Cheng Jiahui Yang Jiawei Ying Guangxiao Yin Fang Cao Weidan Wang Pinqiao Yi Haiyao Wang Liqun Song Lingpeng Liu Xiaohu Wang Lu Li Dewei Zhao |
| author_facet | Junlei Li Liangliang Cheng Jiahui Yang Jiawei Ying Guangxiao Yin Fang Cao Weidan Wang Pinqiao Yi Haiyao Wang Liqun Song Lingpeng Liu Xiaohu Wang Lu Li Dewei Zhao |
| author_sort | Junlei Li |
| collection | DOAJ |
| description | Porous tantalum (Ta) has exhibited exceptional biocompatibility and osseointegration capacity as an advanced orthopedic implant material. This study employs selective laser melting (SLM) to fabricate porous Ta scaffolds with controlled porosities (65 %, 75 %, 85 %, 90 %), systematically investigating their structure-property relationship for bone tissue engineering applications. Results demonstrate that SLM-fabricated porous Ta scaffolds possess biomechanical properties comparable to native bone tissue while maintaining superior fatigue resistance. In vitro assessments confirm the scaffolds’ excellent cytocompatibility, with porosity levels significantly affecting MC3T3-E1 pre-osteoblast differentiation. Notably, scaffolds with 75 % porosity induced optimal osteogenic differentiation, as evidenced by enhanced mineralization markers. Porous Ta scaffolds with 75 % porosity were implanted in rabbit femoral condyles for bone defect repair. Quantitative analysis revealed progressive osseointegration, with bone ingrowth area ratios measuring 7.4 ± 3.4 % at 4 weeks and 21.7 ± 5.5 % at 12 weeks post-implantation. In parallel large-animal trials, 75 % porosity scaffolds were successfully deployed in goat femoral defects. After 12 weeks of implantation, VG staining confirmed distinct bone ingrowth within the scaffolds, while mechanical evaluation demonstrated sustained load-bearing capacity sufficient for femoral defect stabilization. |
| format | Article |
| id | doaj-art-b6b3219c5bbc43f5aff2fe195d685e67 |
| institution | Kabale University |
| issn | 2238-7854 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj-art-b6b3219c5bbc43f5aff2fe195d685e672025-08-20T03:48:15ZengElsevierJournal of Materials Research and Technology2238-78542025-05-01369320933210.1016/j.jmrt.2025.05.195Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterialJunlei Li0Liangliang Cheng1Jiahui Yang2Jiawei Ying3Guangxiao Yin4Fang Cao5Weidan Wang6Pinqiao Yi7Haiyao Wang8Liqun Song9Lingpeng Liu10Xiaohu Wang11Lu Li12Dewei Zhao13Corresponding author.; Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaDepartment of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaCorresponding author.; Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, ChinaPorous tantalum (Ta) has exhibited exceptional biocompatibility and osseointegration capacity as an advanced orthopedic implant material. This study employs selective laser melting (SLM) to fabricate porous Ta scaffolds with controlled porosities (65 %, 75 %, 85 %, 90 %), systematically investigating their structure-property relationship for bone tissue engineering applications. Results demonstrate that SLM-fabricated porous Ta scaffolds possess biomechanical properties comparable to native bone tissue while maintaining superior fatigue resistance. In vitro assessments confirm the scaffolds’ excellent cytocompatibility, with porosity levels significantly affecting MC3T3-E1 pre-osteoblast differentiation. Notably, scaffolds with 75 % porosity induced optimal osteogenic differentiation, as evidenced by enhanced mineralization markers. Porous Ta scaffolds with 75 % porosity were implanted in rabbit femoral condyles for bone defect repair. Quantitative analysis revealed progressive osseointegration, with bone ingrowth area ratios measuring 7.4 ± 3.4 % at 4 weeks and 21.7 ± 5.5 % at 12 weeks post-implantation. In parallel large-animal trials, 75 % porosity scaffolds were successfully deployed in goat femoral defects. After 12 weeks of implantation, VG staining confirmed distinct bone ingrowth within the scaffolds, while mechanical evaluation demonstrated sustained load-bearing capacity sufficient for femoral defect stabilization.http://www.sciencedirect.com/science/article/pii/S2238785425013511Selective laser melting (SLM)Porous Ta scaffoldStructure-property relationshipFatigue resistance performanceBone defect |
| spellingShingle | Junlei Li Liangliang Cheng Jiahui Yang Jiawei Ying Guangxiao Yin Fang Cao Weidan Wang Pinqiao Yi Haiyao Wang Liqun Song Lingpeng Liu Xiaohu Wang Lu Li Dewei Zhao Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial Journal of Materials Research and Technology Selective laser melting (SLM) Porous Ta scaffold Structure-property relationship Fatigue resistance performance Bone defect |
| title | Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial |
| title_full | Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial |
| title_fullStr | Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial |
| title_full_unstemmed | Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial |
| title_short | Study on the performance of selected laser melting porous Ta scaffolds with different porosities used as orthopedics implant biomaterial |
| title_sort | study on the performance of selected laser melting porous ta scaffolds with different porosities used as orthopedics implant biomaterial |
| topic | Selective laser melting (SLM) Porous Ta scaffold Structure-property relationship Fatigue resistance performance Bone defect |
| url | http://www.sciencedirect.com/science/article/pii/S2238785425013511 |
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