Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?
The clinical use of bone marrow derived multipotent mesenchymal stromal cells (BM-MSCs) in different settings ranging from tissue engineering to immunotherapies has prompted investigations on the properties of these cells in a variety of other tissues. Particularly the role of MSCs in solid tumors h...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/914632 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850160291092889600 |
|---|---|
| author | Pascal David Johann Ingo Müller |
| author_facet | Pascal David Johann Ingo Müller |
| author_sort | Pascal David Johann |
| collection | DOAJ |
| description | The clinical use of bone marrow derived multipotent mesenchymal stromal cells (BM-MSCs) in different settings ranging from tissue engineering to immunotherapies has prompted investigations on the properties of these cells in a variety of other tissues. Particularly the role of MSCs in solid tumors has been the subject of many experimental approaches. While a clear phenotypical distinction of tumor associated fibroblasts (TAFs) and MSCs within the tumor microenvironment is still missing, the homing of bone marrow MSCs in tumor sites has been extensively studied. Both, tumor-promoting and tumor-inhibiting effects of BM-MSCs have been described in this context. This ambiguity requires a reappraisal of the different studies and experimental methods employed. Here, we review the current literature on tumor-promoting and tumor-inhibiting effects of BM-MSCs with a particular emphasis on their interplay with components of the immune system and also highlight a potential role of MSCs as cell of origin for certain mesenchymal tumors. |
| format | Article |
| id | doaj-art-b6b26b5e39eb488f820d10d5c87b8d1b |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b6b26b5e39eb488f820d10d5c87b8d1b2025-08-20T02:23:11ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/914632914632Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?Pascal David Johann0Ingo Müller1Division of Pediatric Neurooncology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, GermanyDepartment of Pediatric Hematology and Oncology, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, GermanyThe clinical use of bone marrow derived multipotent mesenchymal stromal cells (BM-MSCs) in different settings ranging from tissue engineering to immunotherapies has prompted investigations on the properties of these cells in a variety of other tissues. Particularly the role of MSCs in solid tumors has been the subject of many experimental approaches. While a clear phenotypical distinction of tumor associated fibroblasts (TAFs) and MSCs within the tumor microenvironment is still missing, the homing of bone marrow MSCs in tumor sites has been extensively studied. Both, tumor-promoting and tumor-inhibiting effects of BM-MSCs have been described in this context. This ambiguity requires a reappraisal of the different studies and experimental methods employed. Here, we review the current literature on tumor-promoting and tumor-inhibiting effects of BM-MSCs with a particular emphasis on their interplay with components of the immune system and also highlight a potential role of MSCs as cell of origin for certain mesenchymal tumors.http://dx.doi.org/10.1155/2015/914632 |
| spellingShingle | Pascal David Johann Ingo Müller Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors? Stem Cells International |
| title | Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors? |
| title_full | Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors? |
| title_fullStr | Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors? |
| title_full_unstemmed | Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors? |
| title_short | Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors? |
| title_sort | multipotent mesenchymal stromal cells possible culprits in solid tumors |
| url | http://dx.doi.org/10.1155/2015/914632 |
| work_keys_str_mv | AT pascaldavidjohann multipotentmesenchymalstromalcellspossibleculpritsinsolidtumors AT ingomuller multipotentmesenchymalstromalcellspossibleculpritsinsolidtumors |