Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality
Background: Various factors have been identified as contributors to mortality in coronavirus disease 2019 (COVID-19). This study aims to elucidate the relationship between admission investigations, hourly oxygen saturation (SpO2), and circadian rhythm in COVID-19 mortality. Materials and Methods: A...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-03-01
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| Series: | APIK Journal of Internal Medicine |
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| Online Access: | https://journals.lww.com/10.4103/ajim.ajim_116_23 |
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| author | Madhav Prabhu R. Balasubramanian Harpreet Kour Arathi Darshan Jayaprakash Appajigol Rekhs S. Patil JangBahadur Prasad |
| author_facet | Madhav Prabhu R. Balasubramanian Harpreet Kour Arathi Darshan Jayaprakash Appajigol Rekhs S. Patil JangBahadur Prasad |
| author_sort | Madhav Prabhu |
| collection | DOAJ |
| description | Background:
Various factors have been identified as contributors to mortality in coronavirus disease 2019 (COVID-19). This study aims to elucidate the relationship between admission investigations, hourly oxygen saturation (SpO2), and circadian rhythm in COVID-19 mortality.
Materials and Methods:
A retrospective cross-sectional study was conducted using sociodemographic and laboratory data from the medical records department of a tertiary care hospital. Data from 218 COVID-19 fatalities during the second wave (March 2021–June 2021) were analyzed using means, percentages, averages, correlation, and coefficients of determination with SPSS software version 20.0.
Results:
The majority of deaths occurred in males, the unemployed, those over 60 years, and patients with comorbidities. The study also examined contributing factors in 35.3% of patients who died without comorbidities. Elevated levels of lactate dehydrogenase, interleukin-6, high-sensitivity C-reactive protein, D-dimer, and ferritin were predictive of hypoxemia progression. A notable dip in mean SpO2 at midday indicated circadian rhythm disruption in COVID-19 patients.
Conclusions:
A midday dip in SpO2, likely due to circadian rhythm disruption, was a notable feature in patients who died due to COVID-19. Elevated inflammatory markers are significant predictors of hypoxemia progression. |
| format | Article |
| id | doaj-art-b6b260a98bb84cb099e205572e1acfb4 |
| institution | OA Journals |
| issn | 2666-1802 2666-1810 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | APIK Journal of Internal Medicine |
| spelling | doaj-art-b6b260a98bb84cb099e205572e1acfb42025-08-20T02:11:38ZengWolters Kluwer Medknow PublicationsAPIK Journal of Internal Medicine2666-18022666-18102025-03-0113211111710.4103/ajim.ajim_116_23Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 MortalityMadhav PrabhuR. BalasubramanianHarpreet KourArathi DarshanJayaprakash AppajigolRekhs S. PatilJangBahadur PrasadBackground: Various factors have been identified as contributors to mortality in coronavirus disease 2019 (COVID-19). This study aims to elucidate the relationship between admission investigations, hourly oxygen saturation (SpO2), and circadian rhythm in COVID-19 mortality. Materials and Methods: A retrospective cross-sectional study was conducted using sociodemographic and laboratory data from the medical records department of a tertiary care hospital. Data from 218 COVID-19 fatalities during the second wave (March 2021–June 2021) were analyzed using means, percentages, averages, correlation, and coefficients of determination with SPSS software version 20.0. Results: The majority of deaths occurred in males, the unemployed, those over 60 years, and patients with comorbidities. The study also examined contributing factors in 35.3% of patients who died without comorbidities. Elevated levels of lactate dehydrogenase, interleukin-6, high-sensitivity C-reactive protein, D-dimer, and ferritin were predictive of hypoxemia progression. A notable dip in mean SpO2 at midday indicated circadian rhythm disruption in COVID-19 patients. Conclusions: A midday dip in SpO2, likely due to circadian rhythm disruption, was a notable feature in patients who died due to COVID-19. Elevated inflammatory markers are significant predictors of hypoxemia progression.https://journals.lww.com/10.4103/ajim.ajim_116_23circadian discordancecoronavirus disease 2019midday dip in oxygen saturation |
| spellingShingle | Madhav Prabhu R. Balasubramanian Harpreet Kour Arathi Darshan Jayaprakash Appajigol Rekhs S. Patil JangBahadur Prasad Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality APIK Journal of Internal Medicine circadian discordance coronavirus disease 2019 midday dip in oxygen saturation |
| title | Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality |
| title_full | Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality |
| title_fullStr | Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality |
| title_full_unstemmed | Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality |
| title_short | Prediction and Correlation of Midnoon Dip in Oxygen Saturation and Circadian Clock Discordance with Coronavirus Disease 2019 Mortality |
| title_sort | prediction and correlation of midnoon dip in oxygen saturation and circadian clock discordance with coronavirus disease 2019 mortality |
| topic | circadian discordance coronavirus disease 2019 midday dip in oxygen saturation |
| url | https://journals.lww.com/10.4103/ajim.ajim_116_23 |
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