Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis
Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/901246 |
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| author | Nadia Innaro Elena Succurro Giuseppe Tomaino Franco Arturi |
| author_facet | Nadia Innaro Elena Succurro Giuseppe Tomaino Franco Arturi |
| author_sort | Nadia Innaro |
| collection | DOAJ |
| description | Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease. |
| format | Article |
| id | doaj-art-b6b10f512d6646cfb52beb728ea60218 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-b6b10f512d6646cfb52beb728ea602182025-02-03T01:09:12ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/901246901246Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto ThyroiditisNadia Innaro0Elena Succurro1Giuseppe Tomaino2Franco Arturi3Department of Surgery, Policlinico “Mater Domini” of Catanzaro, Campus Universitario, Viale Europa, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro Policlinico “Mater Domini”, Campus Universitario, Viale Europa, 88100 Catanzaro, ItalyDepartment of Surgery, Policlinico “Mater Domini” of Catanzaro, Campus Universitario, Viale Europa, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro Policlinico “Mater Domini”, Campus Universitario, Viale Europa, 88100 Catanzaro, ItalyThyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease.http://dx.doi.org/10.1155/2013/901246 |
| spellingShingle | Nadia Innaro Elena Succurro Giuseppe Tomaino Franco Arturi Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis Case Reports in Oncological Medicine |
| title | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
| title_full | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
| title_fullStr | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
| title_full_unstemmed | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
| title_short | Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis |
| title_sort | nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis |
| url | http://dx.doi.org/10.1155/2013/901246 |
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