The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome
Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community. Objectives: The aim of our study was to evaluate...
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2024-09-01
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| author | Mihaela-Andreea Podeanu Ștefănița Bianca Vintilescu Claudiu Marinel Ionele Raluca Elena Sandu Carmen Elena Niculescu Mirela-Marinela Florescu Mioara Desdemona Stepan |
| author_facet | Mihaela-Andreea Podeanu Ștefănița Bianca Vintilescu Claudiu Marinel Ionele Raluca Elena Sandu Carmen Elena Niculescu Mirela-Marinela Florescu Mioara Desdemona Stepan |
| author_sort | Mihaela-Andreea Podeanu |
| collection | DOAJ |
| description | Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community. Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents. Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS. Results: The MetS positive group had higher values of TG/HDL-C (<i>p</i> < 0.001), TC/HDL-C (<i>p</i> < 0.001), MHR (<i>p</i> = 0.015), LHR (<i>p</i> = 0.001), NHR (<i>p</i> = 0.001), atherogenic index of plasma (<i>p</i> < 0.001), and PHR (<i>p</i> < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity. Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents. |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| publishDate | 2024-09-01 |
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| spelling | doaj-art-b6ac67f075ee4aa3968e1b9d7c186d552025-08-20T01:55:38ZengMDPI AGLife2075-17292024-09-01149120610.3390/life14091206The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic SyndromeMihaela-Andreea Podeanu0Ștefănița Bianca Vintilescu1Claudiu Marinel Ionele2Raluca Elena Sandu3Carmen Elena Niculescu4Mirela-Marinela Florescu5Mioara Desdemona Stepan6Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Infant Care, Pediatrics and Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Infant Care, Pediatrics and Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Pathology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Infant Care, Pediatrics and Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaObesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community. Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents. Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS. Results: The MetS positive group had higher values of TG/HDL-C (<i>p</i> < 0.001), TC/HDL-C (<i>p</i> < 0.001), MHR (<i>p</i> = 0.015), LHR (<i>p</i> = 0.001), NHR (<i>p</i> = 0.001), atherogenic index of plasma (<i>p</i> < 0.001), and PHR (<i>p</i> < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity. Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.https://www.mdpi.com/2075-1729/14/9/1206obesitymetabolic syndromeinflammationinflammatory indexescardioembolic indexeschildren |
| spellingShingle | Mihaela-Andreea Podeanu Ștefănița Bianca Vintilescu Claudiu Marinel Ionele Raluca Elena Sandu Carmen Elena Niculescu Mirela-Marinela Florescu Mioara Desdemona Stepan The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome Life obesity metabolic syndrome inflammation inflammatory indexes cardioembolic indexes children |
| title | The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome |
| title_full | The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome |
| title_fullStr | The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome |
| title_full_unstemmed | The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome |
| title_short | The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome |
| title_sort | role of paraclinical investigations in detecting inflammation in children and adolescents with obesity and metabolic syndrome |
| topic | obesity metabolic syndrome inflammation inflammatory indexes cardioembolic indexes children |
| url | https://www.mdpi.com/2075-1729/14/9/1206 |
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