Single-cell and spatial transcriptomics in endocrine research
Accumulating evidence suggests that cellular heterogeneity in organs and cell-cell and tissue-tissue interactions are crucial for maintaining physical homeostasis and disease progression. Endocrine organs also exhibit cellular heterogeneity and comprise multiple cell types. For instance, the pituita...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-02-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0457/_html/-char/en |
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| _version_ | 1832591726275985408 |
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| author | Ryusaku Matsumoto Takuya Yamamoto |
| author_facet | Ryusaku Matsumoto Takuya Yamamoto |
| author_sort | Ryusaku Matsumoto |
| collection | DOAJ |
| description | Accumulating evidence suggests that cellular heterogeneity in organs and cell-cell and tissue-tissue interactions are crucial for maintaining physical homeostasis and disease progression. Endocrine organs also exhibit cellular heterogeneity and comprise multiple cell types. For instance, the pituitary gland comprises five types of pituitary hormone-producing cells as well as non-hormone-producing supporting cells, such as fibroblasts, endothelial cells, and folliculostellate cells. However, the functional roles of the interactions between hormone-producing and non-producing cells in the pituitary gland remain incompletely understood. Over the past decade, emerging technologies such as single-cell and spatial transcriptomics have provided excellent tools for studying cellular heterogeneity and their interactions; however, the application of these technologies in endocrine research remains limited. This review provides an overview of these technologies and discusses their strengths and limitations. Additionally, we also summarize the potential future applications of single-cell and spatial transcriptomics in the study of endocrine organs and their disorders. |
| format | Article |
| id | doaj-art-b6aae32fe07d4628967e50824672cb5b |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-b6aae32fe07d4628967e50824672cb5b2025-01-22T06:33:21ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-02-0171210111810.1507/endocrj.EJ23-0457endocrjSingle-cell and spatial transcriptomics in endocrine researchRyusaku Matsumoto0Takuya Yamamoto1Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, JapanCenter for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, JapanAccumulating evidence suggests that cellular heterogeneity in organs and cell-cell and tissue-tissue interactions are crucial for maintaining physical homeostasis and disease progression. Endocrine organs also exhibit cellular heterogeneity and comprise multiple cell types. For instance, the pituitary gland comprises five types of pituitary hormone-producing cells as well as non-hormone-producing supporting cells, such as fibroblasts, endothelial cells, and folliculostellate cells. However, the functional roles of the interactions between hormone-producing and non-producing cells in the pituitary gland remain incompletely understood. Over the past decade, emerging technologies such as single-cell and spatial transcriptomics have provided excellent tools for studying cellular heterogeneity and their interactions; however, the application of these technologies in endocrine research remains limited. This review provides an overview of these technologies and discusses their strengths and limitations. Additionally, we also summarize the potential future applications of single-cell and spatial transcriptomics in the study of endocrine organs and their disorders.https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0457/_html/-char/ensingle-cell transcriptomicsspatial transcriptomicscellular heterogeneityintercellular communicationendocrine organ |
| spellingShingle | Ryusaku Matsumoto Takuya Yamamoto Single-cell and spatial transcriptomics in endocrine research Endocrine Journal single-cell transcriptomics spatial transcriptomics cellular heterogeneity intercellular communication endocrine organ |
| title | Single-cell and spatial transcriptomics in endocrine research |
| title_full | Single-cell and spatial transcriptomics in endocrine research |
| title_fullStr | Single-cell and spatial transcriptomics in endocrine research |
| title_full_unstemmed | Single-cell and spatial transcriptomics in endocrine research |
| title_short | Single-cell and spatial transcriptomics in endocrine research |
| title_sort | single cell and spatial transcriptomics in endocrine research |
| topic | single-cell transcriptomics spatial transcriptomics cellular heterogeneity intercellular communication endocrine organ |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0457/_html/-char/en |
| work_keys_str_mv | AT ryusakumatsumoto singlecellandspatialtranscriptomicsinendocrineresearch AT takuyayamamoto singlecellandspatialtranscriptomicsinendocrineresearch |