Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case
Ovarian cancer is one of the most malignant and aggressive tumors of the female reproductive system. Late diagnosis is one of the most significant problems: more than two-thirds of cases are detected only at stage III–IV. Ovarian cancer is characterized by a unique metastatic process. Implantation i...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-01-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/890 |
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| author | E. V. Kaigorodova O. V. Kovalev A. L. Chernyshova S. V. Vtorushin O. V. Shpileva |
| author_facet | E. V. Kaigorodova O. V. Kovalev A. L. Chernyshova S. V. Vtorushin O. V. Shpileva |
| author_sort | E. V. Kaigorodova |
| collection | DOAJ |
| description | Ovarian cancer is one of the most malignant and aggressive tumors of the female reproductive system. Late diagnosis is one of the most significant problems: more than two-thirds of cases are detected only at stage III–IV. Ovarian cancer is characterized by a unique metastatic process. Implantation is the earliest and most common way of metastasis. It is often accompanied by fluid accumulation in the abdominal cavity, known as ascites. We report a case of low-grade serous ovarian carcinoma with a large heterogeneity of tumor cells in the ascitic fluid detected using multicolor flow cytometry. We demonstrated the advantages and benefits of this method in the diagnosis of ovarian cancer. Multicolor flow cytometry opens new horizons for liquid biopsy in oncology. |
| format | Article |
| id | doaj-art-b6a677d9d5c6423bbf63defe3584c29e |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2022-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-b6a677d9d5c6423bbf63defe3584c29e2025-08-20T03:37:53ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272022-01-01174909510.17650/1994-4098-2021-17-4-90-95711Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical caseE. V. Kaigorodova0O. V. Kovalev1A. L. Chernyshova2S. V. Vtorushin3O. V. Shpileva4Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical UniversitySiberian State Medical UniversityCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical UniversityCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesOvarian cancer is one of the most malignant and aggressive tumors of the female reproductive system. Late diagnosis is one of the most significant problems: more than two-thirds of cases are detected only at stage III–IV. Ovarian cancer is characterized by a unique metastatic process. Implantation is the earliest and most common way of metastasis. It is often accompanied by fluid accumulation in the abdominal cavity, known as ascites. We report a case of low-grade serous ovarian carcinoma with a large heterogeneity of tumor cells in the ascitic fluid detected using multicolor flow cytometry. We demonstrated the advantages and benefits of this method in the diagnosis of ovarian cancer. Multicolor flow cytometry opens new horizons for liquid biopsy in oncology.https://ojrs.abvpress.ru/ojrs/article/view/890low-grade ovarian serous carcinomaascitic tumor cellstumor heterogeneityepcammulticolor flow cytometryliquid biopsy |
| spellingShingle | E. V. Kaigorodova O. V. Kovalev A. L. Chernyshova S. V. Vtorushin O. V. Shpileva Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case Опухоли женской репродуктивной системы low-grade ovarian serous carcinoma ascitic tumor cells tumor heterogeneity epcam multicolor flow cytometry liquid biopsy |
| title | Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case |
| title_full | Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case |
| title_fullStr | Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case |
| title_full_unstemmed | Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case |
| title_short | Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case |
| title_sort | heterogeneity of epcam positive cells in low grade serous ovarian carcinoma ascitic fluid a clinical case |
| topic | low-grade ovarian serous carcinoma ascitic tumor cells tumor heterogeneity epcam multicolor flow cytometry liquid biopsy |
| url | https://ojrs.abvpress.ru/ojrs/article/view/890 |
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